Propanoic acid,2-(4-chloro-2-methylphenoxy)-, (2S)-

Base Information

• Chemical Name: Propanoic acid,2-(4-chloro-2-methylphenoxy)-, (2S)-
• CAS No.: 25333-13-5
• Molecular Formula: C10H11 Cl O3
• Molecular Weight: 214.649
• Mol file: 25333-13-5.mol

Synonyms:Propanoicacid, 2-(4-chloro-2-methylphenoxy)-, (S)-; Propionic acid,2-[(4-chloro-o-tolyl)oxy]-, (-)- (8CI);(-)-2-(4-Chloro-2-methylphenoxy)propanoic acid;(-)-2-(4-Chloro-2-methylphenoxy)propionic acid; (-)-Mecoprop; (S)-(-)-Mecoprop;(S)-Mecoprop

Chemical Property of Propanoic acid,2-(4-chloro-2-methylphenoxy)-, (2S)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanoic acid,2-(4-chloro-2-methylphenoxy)-, (2S)-

There total 12 articles about Propanoic acid,2-(4-chloro-2-methylphenoxy)-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

(S)-Ethyl 2-(4-chloro-2-methylphenoxy)propanoate (40390-11-2) → (S)-mecoprop (25333-13-5,18221-59-5,7085-19-0)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1016/S0014-827X(01)01041-2

Reference yield: 15.0%

(RS)-2-(4-chloro-o-tolyloxy)propionic acid (93-65-2,18221-59-5,7085-19-0) → (S)-mecoprop (25333-13-5,18221-59-5,7085-19-0) + (R)-2-methyl-2-(4-chloro-2-methylphenoxy)ethanol (97534-44-6) + (S)-(+)-2-methyl-2-(4-chloro-2-methylphenoxy)ethanol (92446-90-7)

Guidance literature:

for 672h; Yields of byproduct given; Glomerella cingulata;

Reference yield:

(RS)-2-(4-chloro-o-tolyloxy)propionic acid (93-65-2,18221-59-5,7085-19-0) → (R)-Mecoprop (16484-77-8,18221-59-5,7085-19-0) + (S)-mecoprop (25333-13-5,18221-59-5,7085-19-0)

Guidance literature:

With highly sulphated α-cyclodextrin; In ammonium formate aq. buffer; Resolution of racemate; Capillary zone electrophoresis;

DOI:10.1002/jccs.200900167

upstream raw materials:

(RS)-2-(4-chloro-o-tolyloxy)propionic acid

methyl R-2-(4-chloro-2-methylphenoxy)propanoate

(R)-1-(4-pyridinyl)ethanol

2-(4-Chlor-2-methylphenoxy)propionsaeureanhydrid

Downstream raw materials:

(S)-(+)-2-methyl-2-(4-chloro-2-methylphenoxy)ethanol