6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine

Base Information

• Chemical Name: 6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine
• CAS No.: 81861-30-5
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.246
• DSSTox Substance ID: DTXSID90274652
• Nikkaji Number: J3.188.173K
• ChEMBL ID: CHEMBL99215
• Mol file: 81861-30-5.mol

Synonyms:81861-30-5;6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine;6-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine;CHEMBL99215;6-methoxytetralin-2-amine;6-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylamine;2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-6-METHOXY-;2-amino-6-methoxytetralin;SCHEMBL264631;DTXSID90274652;WASIYUSITZITPW-UHFFFAOYSA-N;AMY15315;BDBM50020512;FD7335;MFCD04114915;AKOS015901734;AB19245;4-amino-2,7-difluoro-9h-fluoren-9-one;AS-49313;PD033606;BB 0262730;CS-0378191;FT-0690316;FT-0692891;FT-0770800;EN300-151182;6-Methoxy-1,2,3,4-Tetrahydro-2-Naphthalenamine;6-Methoxy-1,2,3,4-tetrahydronaphthalene-2-amine;2-amino-1,2,3,4-tetrahydro-6-methoxy-naphthalene;2-amino-5-methoxy-1,2,3,4-tetrahydronaphthalene hydrochloride

Chemical Property of 6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine

Chemical Property:

• Boiling Point: 299.6 °C at 760 mmHg
• Flash Point: 139.7 °C
• Density: 1.056 g/cm³
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 177.115364102
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

97% ^*data from raw suppliers

6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(CC(CC2)N)C=C1

Technology Process of 6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine

There total 13 articles about 6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

6-methoxy-3,4-dihydro-[1,2]-naphthoquinone-2-oxime (37563-97-6) → 2-amino-6-methoxy-1,2,3,4-tetrahydronaphthalene (70312-05-9,70312-07-1,81861-30-5,177017-68-4,177017-69-5)

Guidance literature:

With hydrogenchloride; palladium on activated charcoal; hydrogen; In methanol; at 50 ℃; for 20h; under 760.051 Torr;

DOI:10.3109/14756366.2014.940937

Reference yield: 50.0%

6-methoxy-2-tetralone (2472-22-2) → 2-amino-6-methoxy-1,2,3,4-tetrahydronaphthalene (70312-05-9,70312-07-1,81861-30-5,177017-68-4,177017-69-5)

Guidance literature:

6-methoxy-2-tetralone; With ammonium acetate; In methanol; at 20 ℃; for 0.5h;

With sodium cyanoborohydride; for 1 - 2h; Heating / reflux;

Reference yield: 37.0%

terephthalonitrile (623-26-7) + 7-methoxy-1,2-dihydronaphthalene (52178-91-3) → 2-amino-6-methoxy-1,2,3,4-tetrahydronaphthalene (70312-05-9,70312-07-1,81861-30-5,177017-68-4,177017-69-5) + 2-amino-1-(4-cyanophenyl)-6-methoxy-1,2,3,4-tetrahydronaphthalene

Guidance literature:

With ammonia; In water; acetonitrile; for 8h; Irradiation;

DOI:10.1016/S0040-4020(01)85505-8

upstream raw materials:

terephthalonitrile

7-methoxy-1,2-dihydronaphthalene

6-methoxy-3,4-dihydro-[1,2]-naphthoquinone-2-oxime

6-Methoxy-3,4-dihydro-1H-naphthalen-2-one O-methyl-oxime

Downstream raw materials:

2-amino-1,2,3,4-tetrahydro-6-hydroxynaphthalene

[2-(3,4-Dimethoxy-phenyl)-1-methyl-ethyl]-(6-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine; hydrochloride

2-(6-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-isoindole-1,3-dione

2-amino-6-methoxy-1,2,3,4-tetrahydronaphthalene hydrochloride