9-(3,5-di-O-tert-butyldimethylsilyl-4-C-cyano-2-deoxy-ribo-pentofuranosyl)-2,6-dibenzamidopurine

Base Information

Chemical Name:9-(3,5-di-O-tert-butyldimethylsilyl-4-C-cyano-2-deoxy-ribo-pentofuranosyl)-2,6-dibenzamidopurine
CAS No.:583047-67-0
Molecular Formula:C₃₇H₄₉N₇O₅Si₂
Molecular Weight:728.011
Hs Code.:

Synonyms:

Suppliers and Price of 9-(3,5-di-O-tert-butyldimethylsilyl-4-C-cyano-2-deoxy-ribo-pentofuranosyl)-2,6-dibenzamidopurine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-(3,5-di-O-tert-butyldimethylsilyl-4-C-cyano-2-deoxy-ribo-pentofuranosyl)-2,6-dibenzamidopurine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 9-(3,5-di-O-tert-butyldimethylsilyl-4-C-cyano-2-deoxy-ribo-pentofuranosyl)-2,6-dibenzamidopurine

There total 14 articles about 9-(3,5-di-O-tert-butyldimethylsilyl-4-C-cyano-2-deoxy-ribo-pentofuranosyl)-2,6-dibenzamidopurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₇H₅₁N₇O₆Si₂

: 583047-67-0
9-(3,5-di-O-tert-butyldimethylsilyl-4-C-cyano-2-deoxy-ribo-pentofuranosyl)-2,6-dibenzamidopurine

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1081/NCN-120037508

Reference yield:

: 583047-61-4
9-(2-deoxy-ribo-pentofuranosyl)-2,6-dibenzamidopurine

: 583047-67-0
9-(3,5-di-O-tert-butyldimethylsilyl-4-C-cyano-2-deoxy-ribo-pentofuranosyl)-2,6-dibenzamidopurine

Guidance literature:: Multi-step reaction with 12 steps

1: pyridine / 3 h / 20 °C

2: imidazole / dimethylformamide / 20 °C

3: 28.8 g / p-toluenesulfonic acid hydrate / CHCl₃; methanol / 0.25 h / 0 °C

4: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; pyridine; trifluoroacetic acid / toluene; dimethylsulfoxide / 2 h / 20 °C

5: NaOH / dioxane; H₂O / 3 h / 20 °C

6: 30.83 g / NaBH₄ / ethanol / 0.5 h / 0 °C

7: 60.3 percent / triethylamine / dimethylformamide / 1 h / 20 °C

8: imidazole / dimethylformamide / 20 °C

9: 17.5 g / p-toluenesulfonic acid hydrate / CHCl₃; methanol / 0.33 h / 0 °C

10: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; pyridine; trifluoroacetic acid / toluene; dimethylsulfoxide / 1 h / 20 °C

11: hydroxylamine hydrochloride; pyridine / 0.5 h / 20 °C

12: 1.77 g / methanesulfonyl chloride; triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; hydroxylamine hydrochloride; toluene-4-sulfonic acid; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 4: Moffatt oxidation / 10: Moffatt oxidation;
DOI:10.1081/NCN-120037508

Reference yield:

: C₃₀H₃₄N₆O₅Si

: 583047-67-0
9-(3,5-di-O-tert-butyldimethylsilyl-4-C-cyano-2-deoxy-ribo-pentofuranosyl)-2,6-dibenzamidopurine

Guidance literature:: Multi-step reaction with 8 steps

1: NaOH / dioxane; H₂O / 3 h / 20 °C

2: 30.83 g / NaBH₄ / ethanol / 0.5 h / 0 °C

3: 60.3 percent / triethylamine / dimethylformamide / 1 h / 20 °C

4: imidazole / dimethylformamide / 20 °C

5: 17.5 g / p-toluenesulfonic acid hydrate / CHCl₃; methanol / 0.33 h / 0 °C

6: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; pyridine; trifluoroacetic acid / toluene; dimethylsulfoxide / 1 h / 20 °C

7: hydroxylamine hydrochloride; pyridine / 0.5 h / 20 °C

8: 1.77 g / methanesulfonyl chloride; triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; hydroxylamine hydrochloride; toluene-4-sulfonic acid; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 6: Moffatt oxidation;
DOI:10.1081/NCN-120037508