2-(Benzyloxy)-6-chloropyrazine

Base Information

• Chemical Name: 2-(Benzyloxy)-6-chloropyrazine
• CAS No.: 4774-18-9
• Molecular Formula: C11H9ClN2O
• Molecular Weight: 220.658
• Hs Code.: 2933990090
• European Community (EC) Number: 826-549-3
• DSSTox Substance ID: DTXSID10471742
• Mol file: 4774-18-9.mol

Synonyms:2-(benzyloxy)-6-chloropyrazine;4774-18-9;2-chloro-6-phenylmethoxypyrazine;2-benzyloxy-6-chloropyrazine;2-(benzyloxy)-6-chloropyraine;MFCD08691288;Pyrazine, 2-chloro-6-(phenylmethoxy)-;2-benzyloxy-6-chloro-pyrazine;SCHEMBL1134458;DTXSID10471742;AOYRICZDNURREY-UHFFFAOYSA-N;AKOS000200096;AB48357;FS-2941;SY066270;N,N-DIETHYL-PHTHALAMICACIDETHYLESTER;AM20070440;FT-0647136;EN300-26323;A827322;J-506246;Z221593704;2-(Benzyloxy)-6-chloropyrazine

Chemical Property of 2-(Benzyloxy)-6-chloropyrazine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.593
• Boiling Point: 321.362 °C at 760 mmHg
• Flash Point: 148.155 °C
• PSA: 35.01000
• Density: 1.279 g/cm³
• LogP: 2.70900
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 220.0403406
• Heavy Atom Count: 15
• Complexity: 185

Purity/Quality:

97% ^*data from raw suppliers

2-(Benzyloxy)-6-chloropyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CN=CC(=N2)Cl

Technology Process of 2-(Benzyloxy)-6-chloropyrazine

There total 2 articles about 2-(Benzyloxy)-6-chloropyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,6-dichloropyrazine (4774-14-5) + benzyl alcohol (100-51-6,185532-71-2) → 2-(benzyloxy)-6-chloropyrazine (4774-18-9)

Guidance literature:

With sodium hydride; In toluene; at 50 ℃;

DOI:10.1055/s-0034-1378331

Reference yield:

→ 2-(benzyloxy)-6-chloropyrazine (4774-18-9)

Guidance literature:

2.6-Dichlor-pyrazin, Na-benzylat in Bzl. <Δ>;

DOI:10.1039/jr9650006681

Reference yield: 98.0%

2-(benzyloxy)-6-chloropyrazine (4774-18-9) + phenylboronic acid (98-80-6) → 2-benzyloxy-6-phenylpyrazine (1279817-20-7)

Guidance literature:

With potassium phosphate monohydrate; palladium diacetate; In water; isopropyl alcohol; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.3762/bjoc.15.8

upstream raw materials:

2,6-dichloropyrazine

benzyl alcohol

Downstream raw materials:

(3R,4R,5R)-3,4-Bis-benzyloxy-2-(3-benzyloxy-5-chloro-pyrazin-2-yl)-5-benzyloxymethyl-tetrahydro-furan-2-ol

3-Benzyloxy-2-((2S,3S,4R,5R)-3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-5-chloro-pyrazine

2-benzyloxy-6-phenylpyrazine

C₁₈H₁₆N₂O₂