1-(4-methoxyphenyl)-3-(1-(3-methoxypropyl)-6-(4-methylpiperazin-1-yl)-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)thiourea

Base Information

• Chemical Name: 1-(4-methoxyphenyl)-3-(1-(3-methoxypropyl)-6-(4-methylpiperazin-1-yl)-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)thiourea
• CAS No.: 1465825-99-3
• Molecular Formula: C₂₈H₃₃N₇O₅S
• Molecular Weight: 579.68
• Mol file: 1465825-99-3.mol

Synonyms:

Chemical Property of 1-(4-methoxyphenyl)-3-(1-(3-methoxypropyl)-6-(4-methylpiperazin-1-yl)-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)thiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-methoxyphenyl)-3-(1-(3-methoxypropyl)-6-(4-methylpiperazin-1-yl)-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)thiourea

There total 6 articles about 1-(4-methoxyphenyl)-3-(1-(3-methoxypropyl)-6-(4-methylpiperazin-1-yl)-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H26N6O4 (1465826-22-5) + 4-Methoxyphenyl isothiocyanate (2284-20-0) → 1-(4-methoxyphenyl)-3-(1-(3-methoxypropyl)-6-(4-methylpiperazin-1-yl)-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)thiourea (1465825-99-3)

Guidance literature:

In dichloromethane; Reflux;

DOI:10.1016/j.ejmech.2014.01.039

Reference yield:

1-(5-fluoro-2, 4- dinitrophenyl)-4- methylpiperazine (928830-73-3) → 1-(4-methoxyphenyl)-3-(1-(3-methoxypropyl)-6-(4-methylpiperazin-1-yl)-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)thiourea (1465825-99-3)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

2: ammonium formate; palladium 10% on activated carbon / tetrahydrofuran; ethanol

3: acetic acid / tetrahydrofuran; ethanol; 1,4-dioxane / 20 °C

4: dichloromethane / Reflux

With palladium 10% on activated carbon; ammonium formate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;

DOI:10.1016/j.ejmech.2014.01.039

Reference yield:

C15H23N5O5 (1465826-21-4) → 1-(4-methoxyphenyl)-3-(1-(3-methoxypropyl)-6-(4-methylpiperazin-1-yl)-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)thiourea (1465825-99-3)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium formate; palladium 10% on activated carbon / tetrahydrofuran; ethanol

2: acetic acid / tetrahydrofuran; ethanol; 1,4-dioxane / 20 °C

3: dichloromethane / Reflux

With palladium 10% on activated carbon; ammonium formate; acetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;

DOI:10.1016/j.ejmech.2014.01.039

upstream raw materials:

1-(5-fluoro-2, 4- dinitrophenyl)-4- methylpiperazine

C₁₅H₂₃N₅O₅

1-methyl-piperazine

C₂₀H₂₆N₆O₄