1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 1-methyl- (9CI)

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 1-methyl- (9CI)
• CAS No.: 171919-36-1
• Molecular Formula: C9H8N2O
• Molecular Weight: 160.17262
• Hs Code.: 2933990090
• Mol file: 171919-36-1.mol

Synonyms:1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 1-methyl- (9CI);1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde;1-Methy-1H-Pyrrolo[2,3-b]pyridine-3-carbaldehyde

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 1-methyl- (9CI)

Chemical Property:

• Vapor Pressure: 2.12E-05mmHg at 25°C
• Refractive Index: 1.747
• Boiling Point: 334.8 °C at 760 mmHg
• Flash Point: 156.3 °C
• PSA: 34.89000
• Density: 1.21 g/cm³
• LogP: 1.38580
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 1-methyl- (9CI)

There total 8 articles about 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 1-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1H-pyrrolo[2,3-b]pyridin-3-carbaldehyde (4649-09-6) + methyl iodide (74-88-4) → 1-methyl-1H-pyrrolo<2,3-b>pyridine-3-carbaldehyde (171919-36-1)

Guidance literature:

1H-pyrrolo[2,3-b]pyridin-3-carbaldehyde; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

methyl iodide; In tetrahydrofuran; for 2h;

DOI:10.1016/j.tet.2010.01.042

Reference yield: 95.0%

1-methyl-1H-pyrrolo[2,3-b]pyridine (27257-15-4) + dimethyl sulfoxide (67-68-5,8070-53-9) → 1-methyl-1H-pyrrolo<2,3-b>pyridine-3-carbaldehyde (171919-36-1)

Guidance literature:

With ammonium acetate; water; at 150 ℃; for 48h; Inert atmosphere; Sealed tube;

DOI:10.1039/c3ob41510d

Reference yield: 83.1%

1H-pyrrolo[2,3-b]pyridin-3-carbaldehyde (4649-09-6) + carbonic acid dimethyl ester (616-38-6) → 1-methyl-1H-pyrrolo<2,3-b>pyridine-3-carbaldehyde (171919-36-1)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In N,N-dimethyl-formamide; at 90 - 92 ℃; for 23h;

DOI:10.1021/op900256t

upstream raw materials:

1-methyl-1H-pyrrolo[2,3-b]pyridine

N,N-dimethyl-formamide

1H-pyrrolo[2,3-b]pyridin-3-carbaldehyde

methyl iodide

Downstream raw materials:

1-methyl-1H-pyrrolo<2,3-b>pyridine-3-carboxylic acid

1-methyl-3-[(E)-2-nitrovinyl]-1H-pyrrolo[2,3-b]pyridine

C₃₀H₃₃FN₄O₅

trans-4-[1-[[2-[1-methyl-3-(1H-pyrrolo[2,3-b]pyridinyl)]-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid