phosphoric acid dimethyl ester 1-(6-methyl-2-phenyl-4,9-dihydro-pyrimido[4,5-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-3a-yl)-ethyl ester

Base Information

• Chemical Name: phosphoric acid dimethyl ester 1-(6-methyl-2-phenyl-4,9-dihydro-pyrimido[4,5-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-3a-yl)-ethyl ester
• CAS No.: 27512-93-2
• Molecular Formula: C₁₈H₂₂N₅O₄PS
• Molecular Weight: 435.444
• Mol file: 27512-93-2.mol

Synonyms:

Chemical Property of phosphoric acid dimethyl ester 1-(6-methyl-2-phenyl-4,9-dihydro-pyrimido[4,5-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-3a-yl)-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phosphoric acid dimethyl ester 1-(6-methyl-2-phenyl-4,9-dihydro-pyrimido[4,5-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-3a-yl)-ethyl ester

There total 3 articles about phosphoric acid dimethyl ester 1-(6-methyl-2-phenyl-4,9-dihydro-pyrimido[4,5-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-3a-yl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-phenyl-[1,3,4]thiadiazolium; bromide hydrobromide (27497-92-3) + dimethyl acetylphosphonate (17674-28-1) → phosphoric acid dimethyl ester 1-(6-methyl-2-phenyl-4,9-dihydro-pyrimido[4,5-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-3a-yl)-ethyl ester (27512-93-2)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at -60 - -50 ℃;

Reference yield:

phenyl-1,3,4-thiadiazole (4291-14-9) → phosphoric acid dimethyl ester 1-(6-methyl-2-phenyl-4,9-dihydro-pyrimido[4,5-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-3a-yl)-ethyl ester (27512-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / 65 °C

2: Et₃N / dimethylformamide / -60 - -50 °C

With triethylamine; In N,N-dimethyl-formamide;

Reference yield:

4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide (2908-71-6) → phosphoric acid dimethyl ester 1-(6-methyl-2-phenyl-4,9-dihydro-pyrimido[4,5-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-3a-yl)-ethyl ester (27512-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / 65 °C

2: Et₃N / dimethylformamide / -60 - -50 °C

With triethylamine; In N,N-dimethyl-formamide;

upstream raw materials:

3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-phenyl-[1,3,4]thiadiazolium; bromide hydrobromide

dimethyl acetylphosphonate

phenyl-1,3,4-thiadiazole

4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide

Downstream raw materials:

4-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-6-methyl-2-phenyl-4H-[1,3,4]thiadiazin-5-one