H-HIS(1-TRT)-OME HCL

Base Information

• Chemical Name: H-HIS(1-TRT)-OME HCL
• CAS No.: 62715-28-0
• Molecular Formula: C26H25N3O2
• Molecular Weight: 411.503
• Mol file: 62715-28-0.mol

Synonyms:H-HIS(TRT)-OME HCL;1-trityl-histidine methyl ester;H-His(Trt)-OMe;methyl (2S)-2-amino-3-(1-trityl-1H-imidazol-4-yl)propanoate;HISTIDINE(1-TRT)-OME HCL;N-TAU-TRITYL-HISTIDINE METHYL ESTER HYDROCHLORIDE;Nim-trityl-L-histidine methyl ester;N-trityl histidine methyl ester;(S)-2-AMINO-3-(1-TRITYL-1H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER;Nim-triphenylmethyl-L-histidine methyl ester;N-IM-TRITYL-L-HISTIDINE METHYL ESTER HYDROCHLORIDE;H-HIS(T-TRT)-OME HCL;

Chemical Property of H-HIS(1-TRT)-OME HCL

Chemical Property:

• Boiling Point: 555.5±45.0 °C(Predicted)
• PKA: 6.55±0.10(Predicted)
• PSA: 70.14000
• Density: 1.15±0.1 g/cm3(Predicted)
• LogP: 4.46640
• Storage Temp.: -15°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Nim-Trityl-L-histidine methyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-HIS(1-TRT)-OME HCL

There total 10 articles about H-HIS(1-TRT)-OME HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methyl-Nα-(((9H-fluoren-9-yl)methoxy)carbonyl)-Nτ-trityl-L-histidinate (937801-67-7) → Nim-triphenylmethyl-L-histidine methyl ester (62715-28-0)

Guidance literature:

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

DOI:10.1002/chem.201101540

Reference yield: 62.0%

trityl chloride (76-83-5) + l-histidine methyl ester dihydrochloride (4467-54-3,5619-10-3,7389-87-9,18684-16-7,22888-60-4,32381-17-2,92742-29-5,100009-20-9) → Nim-triphenylmethyl-L-histidine methyl ester (62715-28-0)

Guidance literature:

trityl chloride; l-histidine methyl ester dihydrochloride; With triethylamine;

With hydrogenchloride; In water; acetic acid;

DOI:10.1016/j.polymer.2015.03.068

Reference yield:

Nα-benzyloxycarbonyl-Nim-triphenylmethyl-L-histidine methyl ester (68262-63-5) → Nim-triphenylmethyl-L-histidine methyl ester (62715-28-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 25 ℃; for 2.5h; under 760 Torr;

DOI:10.1016/0968-0896(95)00183-2

upstream raw materials:

N^α-benzyloxycarbonyl-N^im-triphenylmethyl-L-histidine methyl ester

2-(S)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-L-histidine methyl ester

l-histidine methyl ester dihydrochloride

1,N^α-bis-benzyloxycarbonyl-histidine methyl ester

Downstream raw materials:

(S)-2-{[1-Phenyl-meth-(E)-ylidene]-amino}-3-(1-trityl-1H-imidazol-4-yl)-propionic acid methyl ester

2-acryloylamino-3-(1-trityl-1H-imidazol-4-yl)-propionic acid methyl ester

Fmoc-(His(Trt))2-OMe

(+)-Methyl (2S)-2-{(3S)-3-[(tert-butoxycarbonyl)amino]pyrrolidinyl}-3-(1-trityl-1H-imidazol-4-yl)Propanoate