4-Methyl-2-morpholinemethanol

Base Information

• Chemical Name: 4-Methyl-2-morpholinemethanol
• CAS No.: 40987-46-0
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.175
• Hs Code.: 2934999090
• Mol file: 40987-46-0.mol

Synonyms:(4-Methylmorpholin-2-yl)methanol;2-Morpholinemethanol, 4-methyl-;

Chemical Property of 4-Methyl-2-morpholinemethanol

Chemical Property:

• Boiling Point: 177.042 °C at 760 mmHg
• Flash Point: 60.873 °C
• PSA: 32.70000
• Density: 1.032 g/cm³
• LogP: -0.75280
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

95% ^*data from raw suppliers

(4-Methyl-2-morpholinyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methyl-2-morpholinemethanol

There total 1 articles about 4-Methyl-2-morpholinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Chlor-2-hydroxy-3-(N-methyl-N-2-hydroxyethyl)-amino-propan (63125-83-7) → 2-(hydroxymethyl)-4-methylmorpholine (40987-46-0) + perhydro-6-hydroxy-4-methyl-1,4-oxazepine (110528-98-8)

Guidance literature:

With sodium hydroxide; at 35 ℃; for 30h; Title compound not separated from byproducts;

DOI:10.1021/jo00232a035

Reference yield: 60.0%

1-(4-chlorophenyl)piperazine dihydrochloride (13078-12-1,38869-46-4) + 2-(hydroxymethyl)-4-methylmorpholine (40987-46-0) + 4-Nitrophenyl chloroformate (7693-46-1) → (4-methylmorpholin-2-yl)methyl 4-(4-chlorophenyl)piperazine-1-carboxylate dihydrochloride

Guidance literature:

2-(hydroxymethyl)-4-methylmorpholine; 4-Nitrophenyl chloroformate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

1-(4-chlorophenyl)piperazine dihydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

With hydrogenchloride; In diethyl ether; dichloromethane;

Reference yield: 44.0%

1-(4-fluorophenylmethyl)piperazine (70931-28-1) + 2-(hydroxymethyl)-4-methylmorpholine (40987-46-0) + 4-Nitrophenyl chloroformate (7693-46-1) → (4-methylmorpholin-2-yl)methyl4-(4-fluorobenzyl)piperazine-1-carboxylate dihydrochloride

Guidance literature:

2-(hydroxymethyl)-4-methylmorpholine; 4-Nitrophenyl chloroformate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

1-(4-fluorophenylmethyl)piperazine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

With hydrogenchloride; In diethyl ether; dichloromethane;

upstream raw materials:

1-Chlor-2-hydroxy-3-(N-methyl-N-2-hydroxyethyl)-amino-propan

Refernces