4,6-Dichloro-2-(4-methylpiperazin-1-yl)pyrimidine

Base Information

Chemical Name:4,6-Dichloro-2-(4-methylpiperazin-1-yl)pyrimidine
CAS No.:84727-44-6
Molecular Formula:C9H12Cl2N4
Molecular Weight:247.12400
Hs Code.:2933990090
DSSTox Substance ID:DTXSID50522363
Wikidata:Q82387557
Mol file:84727-44-6.mol

Synonyms:84727-44-6;4,6-Dichloro-2-(4-methylpiperazin-1-yl)pyrimidine;4,6-Dichloro-2-(4-methyl-piperazin-1-yl)-pyrimidine;DTXSID50522363;AMY27416;AKOS009154254

Suppliers and Price of 4,6-Dichloro-2-(4-methylpiperazin-1-yl)pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4,6-DICHLORO-2-(4-METHYL-PIPERAZIN-1-YL)-PYRIMIDINE 95.00%
5MG
$ 500.79

AccelPharmtech
4,6-dichloro-2-(4-methyl-1-piperazinyl)-Pyrimidine 97.00%
25G
$ 3120.00

AccelPharmtech
4,6-dichloro-2-(4-methyl-1-piperazinyl)-Pyrimidine 97.00%
1G
$ 1530.00

Abosyn
4,6-Dichloro-2-(4-methyl-piperazin-1-yl)-pyrimidine >95%
1g
$ 199.00

Total 4 raw suppliers

Chemical Property of 4,6-Dichloro-2-(4-methylpiperazin-1-yl)pyrimidine

Chemical Property:

PSA：32.26000
LogP:1.53810
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:246.0439018
Heavy Atom Count:15
Complexity:198

Purity/Quality:

98% ^*data from raw suppliers

4,6-DICHLORO-2-(4-METHYL-PIPERAZIN-1-YL)-PYRIMIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)C2=NC(=CC(=N2)Cl)Cl

Technology Process of 4,6-Dichloro-2-(4-methylpiperazin-1-yl)pyrimidine

There total 2 articles about 4,6-Dichloro-2-(4-methylpiperazin-1-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.6%

: 81746-24-9
4,6-dihydroxy-2-(N-methylpiperazino)pyrimidine

: 84727-44-6
4,6-dichloro-2-(N-methylpiperazino)pyrimidine

Guidance literature:: With trichlorophosphate; for 3h; Heating;
DOI:10.1021/jm00158a013

Reference yield:

: 84727-42-4
1-methyl-4-piperazinecarboxamidine hydrogen sulfate

: 84727-44-6
4,6-dichloro-2-(N-methylpiperazino)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) MeONa / 1.) MeOH, reflux, 0.5 h, 2.) MeOH, reflux, 5 h

2: 13.6 percent / POCl₃ / 3 h / Heating

With sodium methylate; trichlorophosphate;
DOI:10.1021/jm00158a013