C₁₆H₁₆N₂O

Base Information

• Chemical Name: C₁₆H₁₆N₂O
• CAS No.: 199277-77-5
• Molecular Formula: C₁₆H₁₆N₂O
• Molecular Weight: 252.316
• Mol file: 199277-77-5.mol

Synonyms:

Chemical Property of C₁₆H₁₆N₂O

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₆N₂O

There total 6 articles about C₁₆H₁₆N₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-bromo-6-methylpyridine (5315-25-3) + (4S)-4-benzyl-4,5-dihydro-1,3-oxazole (75866-71-6) → (S)-4-benzyl-2-(6-methylpyridin-2-yl)-4,5-dihydrooxazoline (199277-77-5)

Guidance literature:

With C₅₈H₈₀O₄P₂Pd; lithium tert-butoxide; In N,N-dimethyl acetamide; at 110 ℃; for 16h; Inert atmosphere;

DOI:10.1002/adsc.201700663

Reference yield: 62.0%

6-chloro-2-picoline (18368-63-3) + (4S)-4-benzyl-4,5-dihydro-1,3-oxazole (75866-71-6) → (S)-4-benzyl-2-(6-methylpyridin-2-yl)-4,5-dihydrooxazoline (199277-77-5)

Guidance literature:

With palladium diacetate; 1,2-bis-(diphenylphosphino)ethane; lithium tert-butoxide; In 1,4-dioxane; at 100 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.5b03041

Reference yield:

2-Cyano-6-methylpyridine (1620-75-3) + L-Phenylalaninol (3182-95-4) → (S)-4-benzyl-2-(6-methylpyridin-2-yl)-4,5-dihydrooxazoline (199277-77-5)

Guidance literature:

With zinc(II) chloride; In chlorobenzene; for 24h; Yield given; Heating;

DOI:10.1016/S0957-4166(97)00425-4

upstream raw materials:

2-Cyano-6-methylpyridine

L-Phenylalaninol

6-chloro-2-picoline

(4S)-4-benzyl-4,5-dihydro-1,3-oxazole

Refernces

• 1、 Qian, Deyun,Hu, Xile. "Ligand-Controlled Regiodivergent Hydroalkylation of Pyrrolines". supporting information. p. 18519 - 18523. Retrieved 2019/11/22.
• 2、 Ghorai, Debasish,Müller, Valentin,Keil, Helena,Stalke, Dietmar,Zanoni, Giuseppe,Tkachenko, Boryslav A.,Schreiner, Peter R.,Ackermann, Lutz. "Secondary Phosphine Oxide Preligands for Palladium-Catalyzed C–H (Hetero)Arylations: Efficient Access to Pybox Ligands". supporting information. p. 3137 - 3141. Retrieved 2017/09/06.