C₂₅H₃₀N₂O₂

Base Information

• Chemical Name: C₂₅H₃₀N₂O₂
• CAS No.: 1319054-99-3
• Molecular Formula: C₂₅H₃₀N₂O₂
• Molecular Weight: 390.525
• Mol file: 1319054-99-3.mol

Synonyms:

Chemical Property of C₂₅H₃₀N₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₃₀N₂O₂

There total 6 articles about C₂₅H₃₀N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

C25H28N2O3 (1319054-98-2) → C25H30N2O2 (1319054-99-3)

Guidance literature:

With hydrazine hydrate; potassium hydroxide; In diethylene glycol; for 72h; Reflux;

DOI:10.1016/j.bmcl.2011.05.066

Reference yield:

5-bromo-2-pyridylamine (1072-97-5) → C25H30N2O2 (1319054-99-3)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl acetamide; mineral oil / 1 h / 0 °C

2: tri-tert-butyl phosphine; lithium dicyclohexylamide; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 20 °C

3: lithium borohydride / tetrahydrofuran / 48 h / 20 °C

4: Dess-Martin periodane / dichloromethane / 0.17 h / 20 °C

5: hydrazine hydrate; potassium hydroxide / diethylene glycol / 72 h / Reflux

With lithium borohydride; tri-tert-butyl phosphine; sodium hydride; lithium dicyclohexylamide; Dess-Martin periodane; hydrazine hydrate; potassium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; toluene; mineral oil; diethylene glycol; 5: Wolff-Kishner reduction;

DOI:10.1016/j.bmcl.2011.05.066

Reference yield:

C26H30N2O4 (1319054-94-8) → C25H30N2O2 (1319054-99-3)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium borohydride / tetrahydrofuran / 48 h / 20 °C

2: Dess-Martin periodane / dichloromethane / 0.17 h / 20 °C

3: hydrazine hydrate; potassium hydroxide / diethylene glycol / 72 h / Reflux

With lithium borohydride; Dess-Martin periodane; hydrazine hydrate; potassium hydroxide; In tetrahydrofuran; dichloromethane; diethylene glycol; 3: Wolff-Kishner reduction;

DOI:10.1016/j.bmcl.2011.05.066

upstream raw materials:

5-bromo-2-pyridylamine

C₂₆H₃₀N₂O₄

C₂₅H₃₀N₂O₃

C₂₅H₂₈N₂O₃