Methyl 2-chloroquinazolin...

Base Information

• Chemical Name: Methyl 2-chloroquinazolin...
• CAS No.: 953039-79-7
• Molecular Formula: C10H7ClN2O2
• Molecular Weight: 222.631
• Hs Code.: 2933990090
• Mol file: 953039-79-7.mol

Synonyms:methyl 2-chloroquinazolin-7-carboxylate; methyl 2-chloro-quinazoline-7-carboxylate

Chemical Property of Methyl 2-chloroquinazolin...

Chemical Property:

• Boiling Point: 328.627 °C at 760 mmHg
• PKA: -0.73±0.30(Predicted)
• Flash Point: 152.548 °C
• PSA: 52.08000
• Density: 1.393 g/cm³
• LogP: 2.06980

Purity/Quality:

97% ^*data from raw suppliers

methyl2-chloroquinazoline-7-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-chloroquinazolin...

There total 4 articles about Methyl 2-chloroquinazolin... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

methyl 2,4-dichloroquinazoline-7-carboxylate (174074-89-6) → methyl 2-chloroquinazoline-7-carboxylate (953039-79-7)

Guidance literature:

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium; In ethyl acetate; at 20 ℃; for 1h;

Reference yield: 60.0%

methyl 2-hydroxy-quinazoline-7-carboxylate (953039-78-6) → methyl 2-chloroquinazoline-7-carboxylate (953039-79-7)

Guidance literature:

With trichlorophosphate; at 110 ℃; for 0.333333h;

Reference yield:

methyl 4-formyl-3-nitrobenzoate (153813-69-5) → methyl 2-chloroquinazoline-7-carboxylate (953039-79-7)

Guidance literature:

Multi-step reaction with 3 steps

1: iron; acetic acid / ethanol / 1 h

2: 16 h / 145 °C

3: trichlorophosphate / 0.33 h / 110 °C

With iron; acetic acid; trichlorophosphate; In ethanol;

upstream raw materials:

methyl 2-hydroxy-quinazoline-7-carboxylate

methyl 2,4-dichloroquinazoline-7-carboxylate

methyl 3-amino-4-formylbenzoate

methyl 4-formyl-3-nitrobenzoate