2-(2-chloro-5-nitrophenyl)pyridine

Base Information

• Chemical Name: 2-(2-chloro-5-nitrophenyl)pyridine
• CAS No.: 879088-40-1
• Molecular Formula: C11H7ClN2O2
• Molecular Weight: 234.642
• Hs Code.: 2933399090
• Mol file: 879088-40-1.mol

Synonyms:4-chloro-3-(pyridin-2-yl)nitrobenzene;2-(2-pyridyl)-4-nitrochlorobenzene;2,9,16,23-TETRAPHENYL-29H,31H-PHTHALOCYANINE;2-(2-chloranyl-5-nitro-phenyl)pyridine;

Chemical Property of 2-(2-chloro-5-nitrophenyl)pyridine

Chemical Property:

• PSA: 58.71000
• LogP: 3.83340
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Chloro-5-nitrophenyl)pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(2-Chloro-5-nitrophenyl)pyridine is used in the synthesis of Vismondegib (V674700) a hedgehog pathway inhibitor. 2-(2-Chloro-5-nitrophenyl)pyridine is used in the synthesis of Vismondegib (V674700) a hedgehog pathway inhibitor

Technology Process of 2-(2-chloro-5-nitrophenyl)pyridine

There total 39 articles about 2-(2-chloro-5-nitrophenyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-bromo-pyridine (109-04-6) + (2-chloro-5-nitrophenyl)boronic acid (867333-29-7) → 2-(2-chloro-5-nitrophenyl)-pyridine (879088-40-1)

Guidance literature:

With palladium diacetate; potassium carbonate; In water; isopropyl alcohol; at 25 ℃; for 3h;

Reference yield: 96.0%

2'-chloro-5'-nitroacetophenone (23082-50-0) + Trimethylenediamine (109-76-2,54018-94-9) → 2-(2-chloro-5-nitrophenyl)-pyridine (879088-40-1)

Guidance literature:

With oxygen; palladium diacetate; toluene-4-sulfonic acid; In tetrahydrofuran; Reflux;

Reference yield: 95.0%

Ν-oxo-2-(2-chloro-5-nitrophenyl)pyridine → 2-(2-chloro-5-nitrophenyl)-pyridine (879088-40-1)

Guidance literature:

With phosphorus trichloride; In chloroform; for 2h; Reflux;

upstream raw materials:

3-bromo-4-chloronitrobenzene

1-chloro-2-iodo-4-nitrobenzene

2-pyridyl zinc iodide

2-(3-nitrophenyl)pyridine

Downstream raw materials:

vismodegib

4-chloro-3-(pyridin-2-yl)benzeneamine

Refernces

• 1、 Li, Yiming,Rizvi, S. Aal-e-Ali,Hu, Deqing,Sun, Danwen,Gao, Anhui,Zhou, Yubo,Li, Jia,Jiang, Xuefeng. "Selective Late-Stage Oxygenation of Sulfides with Ground-State Oxygen by Uranyl Photocatalysis". . p. 13499 - 13506. Retrieved 2019/08/21.
• 2、 -. "Synthetic Path To Pharmaceutically Acceptable Vismodegib". . . Retrieved 2018/10/19.