2-(3-NITROPHENYL)PYRIDINE

Base Information

• Chemical Name: 2-(3-NITROPHENYL)PYRIDINE
• CAS No.: 4253-79-6
• Molecular Formula: C11H8 N2 O2
• Molecular Weight: 200.197
• Hs Code.: 2933399090
• Mol file: 4253-79-6.mol

Synonyms:Pyridine,2-(m-nitrophenyl)- (6CI,7CI,8CI); 2-(3-Nitrophenyl)pyridine;2-(m-Nitrophenyl)pyridine

Chemical Property of 2-(3-NITROPHENYL)PYRIDINE

Chemical Property:

• PSA: 58.71000
• LogP: 3.18000

Purity/Quality:

95% ^*data from raw suppliers

2-(3-Nitrophenyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-NITROPHENYL)PYRIDINE

There total 28 articles about 2-(3-NITROPHENYL)PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

m-nitrobenzene boronic acid (13331-27-6) + pyridin-2-yl sulfurofluoridate (127827-58-1) → 2-(3-nitrophenyl)pyridine (4253-79-6)

Guidance literature:

With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; In ethanol; water; at 35 ℃; for 5h; chemoselective reaction;

DOI:10.1002/chem.201600167

Reference yield: 92.0%

2-(3-nitrophenyl)pyridine 1-oxide (103985-13-3) → 2-(3-nitrophenyl)pyridine (4253-79-6)

Guidance literature:

With phosphorus trichloride; In chloroform; for 12h; Reflux;

Reference yield: 92.0%

Trimethylenediamine (109-76-2,54018-94-9) + 3-Nitroacetophenone (121-89-1) → 2-(3-nitrophenyl)pyridine (4253-79-6)

Guidance literature:

With oxygen; palladium diacetate; toluene-4-sulfonic acid; In tetrahydrofuran; for 8h; Reflux;

DOI:10.1016/j.tetlet.2016.12.075

upstream raw materials:

pyridine

3-nitrophenyldiazonium chloride

sulfuric acid

m-nitrobromobenzene

Downstream raw materials:

2-(2-chloro-5-nitrophenyl)-pyridine

4-chloro-3-(pyridin-2-yl)benzeneamine

vismodegib

2-chloro-6-[3-(2-pyridyl)phenylamino]-9-iso-propylpurine

Refernces

• 1、 Liu, Xuexin,Chen, Jian,Yang, Chunyan,Wu, Zhouping,Li, Zhiyang,Shi, Yuesen,Huang, Tianle,Yang, Zhongzhen,Wu, Yong. "Three-Component Couplings among Heteroarenes, Difluorocyclopropenes, and Water via C-H Activation". supporting information. p. 6831 - 6835. Retrieved 2021/09/08.
• 2、 Bartolomeu, Aloisio De A.,Brocksom, Timothy J.,De Oliveira, Kleber T.,No?l, Timothy,Silva, Rodrigo C.. "Photoarylation of Pyridines Using Aryldiazonium Salts and Visible Light: An EDA Approach". . . Retrieved 2019/08/26.