(4-CHLOROPHENYL)PHENYLMETHYLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: (4-CHLOROPHENYL)PHENYLMETHYLAMINE HYDROCHLORIDE
• CAS No.: 28022-43-7
• Molecular Formula: C13H12ClN
• Molecular Weight: 217.698
• Hs Code.: 2921499090
• Mol file: 28022-43-7.mol

Synonyms:Benzenemethanamine, 4-chloro-α-phenyl-;Benzylamine,p-chloro-a-phenyl- (6CI,8CI);4-Chlorobenzhydrylamine Hydrochloride;4-Chlorobenzhydrylamine;[(4-Chlorophenyl)phenylmethyl]amine;p-Chlorobenzhydrylamine;Benzenemethanamine, 4-chloro-α-phenyl-;

Chemical Property of (4-CHLOROPHENYL)PHENYLMETHYLAMINE HYDROCHLORIDE

Chemical Property:

• Melting Point: 300-305oC (dec.)(lit.)
• Boiling Point: 336.85 °C at 760 mmHg
• Flash Point: 194.302 °C
• PSA: 26.02000
• Density: 1.175 g/cm³
• LogP: 4.89040
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-α-phenyl-benzenemethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloro-alpha-phenyl-benzenemethanamine is a component of the antihistamine Cetirizine. As a result, 4-Chloro-alpha-phenyl-benzenemethanamine has been used to study Cetrizine’s absorption, distribution, metabolism and excretion.

Technology Process of (4-CHLOROPHENYL)PHENYLMETHYLAMINE HYDROCHLORIDE

There total 22 articles about (4-CHLOROPHENYL)PHENYLMETHYLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Phenyl N-(4-chlorobenzhydryl)carbamate → p-chlorobenzhydrylamine (28022-43-7)

Guidance literature:

With lithium hydroxide; water; In acetonitrile; at 50 ℃; for 3h;

DOI:10.1055/s-2000-6391

Reference yield: 93.0%

→ p-chlorobenzhydrylamine (28022-43-7)

Guidance literature:

With acetic acid; zinc; at 0 - 20 ℃; for 4h; Inert atmosphere;

Reference yield: 81.0%

4-chlorophenyl(phenyl)methane (831-81-2) → p-chlorobenzhydrylamine (28022-43-7)

Guidance literature:

4-chlorophenyl(phenyl)methane; With Benzophenone imine; tetrabutylammonium perchlorate; In acetonitrile; tert-butyl alcohol; at 30 ℃; Electrolysis;

With hydrogenchloride; In methanol; at 50 ℃;

DOI:10.1021/acs.joc.1c01647

upstream raw materials:

(Z)-(4-chlorophenyl)(phenyl)methanone oxime

(E)-(4-chlorophenyl)(phenyl)methanone oxime

4-chlorobenzophenone

phenylethynylmagnesium bromide

Downstream raw materials:

(4-chloro-benzhydryl)-(1-methyl-pyrrolidin-2-ylmethyl)-amine

N-(2-chloro-ethyl)-N'-(4-chloro-benzhydryl)-urea

(+)-4-chloro-benzhydrylamine

(-)-(4-chlorophenyl)(phenyl)methanamine