trans-2-Phenylcyclopropanecarboxylic hydrazide

Base Information

• Chemical Name: trans-2-Phenylcyclopropanecarboxylic hydrazide
• CAS No.: 14561-40-1
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.218
• European Community (EC) Number: 604-482-9
• UNII: 6O4HWU99NA
• Wikidata: Q27265214
• ChEMBL ID: CHEMBL1886849
• Mol file: 14561-40-1.mol

Synonyms:trans-2-Phenylcyclopropanecarboxylic hydrazide;14561-40-1;Tranylcypromine hydrazide, trans-;UNII-6O4HWU99NA;6O4HWU99NA;(+/-)-trans-2-Phenylcyclopropanecarbohydrazide;(1S,2S)-2-phenylcyclopropane-1-carbohydrazide;Cyclopropanecarboxylic acid, 2-phenyl-, hydrazide, (1R,2R)-rel-;Tranylcypromine sulfate impurity, trans-hydrazide- [USP];MLS000332095;trans-tranylcypromine hydrazide;CHEMBL1886849;HMS2616E12;AKOS006323535;SMR000221545;Q27265214;(1S,2S)-2-Phenyl-cyclopropanecarboxylic acid hydrazide;TRANYLCYPROMINE SULFATE IMPURITY, TRANS-HYDRAZIDE- [USP IMPURITY]

Chemical Property of trans-2-Phenylcyclopropanecarboxylic hydrazide

Chemical Property:

• Vapor Pressure: 3.62E-06mmHg at 25°C
• Melting Point: 124-126.5 °C(Solv: water (7732-18-5))
• Boiling Point: 386.1±22.0 °C(Predicted)
• PKA: 13.37±0.40(Predicted)
• Density: 1.218±0.06 g/cm3(Predicted)
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 176.094963011
• Heavy Atom Count: 13
• Complexity: 199

Purity/Quality:

99.9% ^*data from raw suppliers

trans-2-PhenylcyclopropanecarboxylicHydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1C(C1C(=O)NN)C2=CC=CC=C2
• Isomeric SMILES: C1[C@@H]([C@H]1C(=O)NN)C2=CC=CC=C2
• Uses: trans-2-Phenylcyclopropanecarboxylic Hydrazide can be used as reactant/reagent in preparation of phenylcyclopropyl-indolecarboxylate as umifenovir analog and its cytotoxicity and antiviral activity.

Technology Process of trans-2-Phenylcyclopropanecarboxylic hydrazide

There total 6 articles about trans-2-Phenylcyclopropanecarboxylic hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-2-phenylcyclopropane-1-carboxylic acid (939-90-2) → 2-phenyl-cyclopropanecarboxylic acid hydrazide (14561-40-1,14814-55-2,17364-52-2)

Guidance literature:

Multistep reaction; (i) CH₂N₂, (ii) N₂H₄*H₂O;

DOI:10.1021/jo01082a600

Reference yield:

cis-methyl 2-phenylcyclopropane-1-carboxylate (67528-62-5) → (+/-)-cis-2-phenyl-cyclopropane-carboxylic acid-(1)-hydrazide (14561-40-1,14814-55-2,17364-52-2)

Guidance literature:

With ethanol; hydrazine hydrate;

DOI:10.1021/ja01186a062

Reference yield:

methyl trans-2-phenylcyclopropanecarboxylate (5861-31-4,16205-72-4) → 2-phenyl-cyclopropanecarboxylic acid hydrazide (14561-40-1,14814-55-2,17364-52-2)

Guidance literature:

With ethanol; hydrazine hydrate;

DOI:10.1021/ja01186a062

upstream raw materials:

cis-methyl 2-phenylcyclopropane-1-carboxylate

(1S*,2R*)-2-phenylcyclopropane-1-carboxylic acid

methyl trans-2-phenylcyclopropanecarboxylate

trans-2-phenylcyclopropane-1-carboxylic acid

Downstream raw materials:

(+/-)-cis-2-phenyl-cyclopropane-carboxylic acid-⁽¹⁾-isopropylidenehydrazide

rac-cis-2-phenylcyclopropan-1-amine