C₃₃H₃₃N₁₃O₂

Base Information

• Chemical Name: C₃₃H₃₃N₁₃O₂
• CAS No.: 1300713-25-0
• Molecular Formula: C₃₃H₃₃N₁₃O₂
• Molecular Weight: 643.711
• Mol file: 1300713-25-0.mol

Synonyms:

Chemical Property of C₃₃H₃₃N₁₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₃₃N₁₃O₂

There total 5 articles about C₃₃H₃₃N₁₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-amino-2-azidoethane (87156-40-9) + C29H21N5O2 (1300713-24-9) → C33H33N13O2 (1300713-25-0)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 12h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/chem.201003157

Reference yield:

C25H19N3O4 (1050214-81-7) → C33H33N13O2 (1300713-25-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / tetrahydrofuran; methanol / 12 h / 20 °C / Inert atmosphere

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 10 h / 20 °C / Inert atmosphere

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 12 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; copper(ll) sulfate pentahydrate; benzotriazol-1-ol; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol; 3: Huisgen cycloaddition;

DOI:10.1002/chem.201003157

Reference yield:

4-amino-3-iodobenzoic acid methyl ester (19718-49-1) → C33H33N13O2 (1300713-25-0)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 7 h / 20 °C / Inert atmosphere

2: sodium hydroxide / tetrahydrofuran; methanol / 12 h / 20 °C / Inert atmosphere

3: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 10 h / 20 °C / Inert atmosphere

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 12 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper(ll) sulfate pentahydrate; benzotriazol-1-ol; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol; 4: Huisgen cycloaddition;

DOI:10.1002/chem.201003157

upstream raw materials:

C₂₅H₁₉N₃O₄

C₂₃H₁₅N₃O₄

1-amino-2-azidoethane

C₂₉H₂₁N₅O₂