2,2,4-trimethyl-8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-(methylsulfonyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

Base Information

Chemical Name:2,2,4-trimethyl-8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-(methylsulfonyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
CAS No.:1820889-23-3
Molecular Formula:C₂₀H₂₁N₃O₅S
Molecular Weight:415.47
Hs Code.:

Synonyms:

Suppliers and Price of 2,2,4-trimethyl-8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-(methylsulfonyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
INCB057643 >98%
100 mg
$ 650.00

DC Chemicals
INCB057643 >98%
250 mg
$ 1300.00

DC Chemicals
INCB057643 >98%
1 g
$ 2600.00

Crysdot
INCB-057643 99%
25mg
$ 676.00

Crysdot
INCB-057643 99%
100mg
$ 2058.00

Crysdot
INCB-057643 99%
50mg
$ 1176.00

Crysdot
INCB-057643 99%
5mg
$ 215.00

Crysdot
INCB-057643 99%
2mg
$ 144.00

Crysdot
INCB-057643 99%
10mg
$ 343.00

ChemScene
INCB-057643 98.91%
5mg
$ 220.00

Total 9 raw suppliers

Chemical Property of 2,2,4-trimethyl-8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-(methylsulfonyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

Chemical Property:

Boiling Point:787.7±60.0 °C(Predicted)
Density:1.370±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

INCB057643 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses INCB-057643, is a novel, orally bioavailable BET inhibitor.

Technology Process of 2,2,4-trimethyl-8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-(methylsulfonyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

There total 10 articles about 2,2,4-trimethyl-8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-(methylsulfonyl)-2H-benzo[b][1,4]oxazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.5%

: 2,2,4-trimethyl-8-(6-methyl-7-oxo-1-tosyl-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-(methylsulfonyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

: 1820889-23-3
2,2,4-trimethyl-8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-(methylsulfonyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; Inert atmosphere; Large scale;

Reference yield:

: 14763-60-1
4-methanesulfonyl-phenol

: 1820889-23-3
2,2,4-trimethyl-8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-(methylsulfonyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: nitric acid; acetic acid / 4 h / 70 - 80 °C

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 2.17 h / 0 - 20 °C / Large scale

3: sodium hydrogencarbonate; sodium dithionite / tetrahydrofuran; water / 2 h / 20 °C / Large scale

4: potassium carbonate; hydrogenchloride / water; acetonitrile / 20 - 75 °C

5: potassium carbonate / N,N-dimethyl-formamide / 4 h / 17 °C / Inert atmosphere; Large scale

6: cesium fluoride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / Inert atmosphere; Reflux

7: sodium hydroxide / water; 1,4-dioxane / Inert atmosphere; Large scale

With hydrogenchloride; N-Bromosuccinimide; sodium dithionite; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); nitric acid; sodium hydrogencarbonate; potassium carbonate; acetic acid; cesium fluoride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 4-bromo-1-(4-methylbenzenesulfonyl)pyrrolo[2,3-c]pyridin-7-ol

: 1820889-23-3
2,2,4-trimethyl-8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-(methylsulfonyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / Large scale

1.2: 2.5 h / Large scale

2.1: sodium hydrogencarbonate / water; 1,4-dioxane / 2.5 h / 89 °C / Inert atmosphere; Large scale

3.1: sodium hydroxide / water; 1,4-dioxane / Inert atmosphere; Large scale

With sodium hydride; sodium hydrogencarbonate; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;