5'-O-levulinyl-2'-O-(methoxytetrahydropyranyl)-6-N-(p-anisoyl)adenosine 3'-O-(2,2,2-tribromoethyl 2-chloro-4-tert-butylphenyl phosphate)

Base Information

• Chemical Name: 5'-O-levulinyl-2'-O-(methoxytetrahydropyranyl)-6-N-(p-anisoyl)adenosine 3'-O-(2,2,2-tribromoethyl 2-chloro-4-tert-butylphenyl phosphate)
• CAS No.: 80235-23-0
• Molecular Formula: C₄₁H₄₈Br₃ClN₅O₁₃P
• Molecular Weight: 1125
• Mol file: 80235-23-0.mol

Synonyms:

Chemical Property of 5'-O-levulinyl-2'-O-(methoxytetrahydropyranyl)-6-N-(p-anisoyl)adenosine 3'-O-(2,2,2-tribromoethyl 2-chloro-4-tert-butylphenyl phosphate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-levulinyl-2'-O-(methoxytetrahydropyranyl)-6-N-(p-anisoyl)adenosine 3'-O-(2,2,2-tribromoethyl 2-chloro-4-tert-butylphenyl phosphate)

There total 3 articles about 5'-O-levulinyl-2'-O-(methoxytetrahydropyranyl)-6-N-(p-anisoyl)adenosine 3'-O-(2,2,2-tribromoethyl 2-chloro-4-tert-butylphenyl phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N6-(4-methoxy-benzoyl)-O2'-(4-methoxy-tetrahydro-pyran-4-yl)-adenosine (60943-91-1) → 5'-O-levulinyl-2'-O-(methoxytetrahydropyranyl)-6-N-(p-anisoyl)adenosine 3'-O-(2,2,2-tribromoethyl 2-chloro-4-tert-butylphenyl phosphate) (80235-23-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / 2-chloro-1-methylpyridinium iodide, 1,4-diazabicyclo<2.2.2>octane / acetonitrile; dioxane / 2 h

2: 1.) 1-methylimidazole; 2.) pyridine, water / 1.) acetonitrile; 2.) 30 min

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; 1-methyl-1H-imidazole; 2-chloro-1-methyl-pyridinium iodide; water; In 1,4-dioxane; acetonitrile;

Reference yield:

levulinic acid (123-76-2) → 5'-O-levulinyl-2'-O-(methoxytetrahydropyranyl)-6-N-(p-anisoyl)adenosine 3'-O-(2,2,2-tribromoethyl 2-chloro-4-tert-butylphenyl phosphate) (80235-23-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / 2-chloro-1-methylpyridinium iodide, 1,4-diazabicyclo<2.2.2>octane / acetonitrile; dioxane / 2 h

2: 1.) 1-methylimidazole; 2.) pyridine, water / 1.) acetonitrile; 2.) 30 min

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; 1-methyl-1H-imidazole; 2-chloro-1-methyl-pyridinium iodide; water; In 1,4-dioxane; acetonitrile;

Reference yield:

4-Oxo-pentanoic acid (2R,3R,4R,5R)-3-hydroxy-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester (69497-76-3) + 2,2,2,-tribromoethyl 2-chloro-4-tert-butylphenyl phosphorochloridate (69919-18-2) → 5'-O-levulinyl-2'-O-(methoxytetrahydropyranyl)-6-N-(p-anisoyl)adenosine 3'-O-(2,2,2-tribromoethyl 2-chloro-4-tert-butylphenyl phosphate) (80235-23-0)

Guidance literature:

With pyridine; 1-methyl-1H-imidazole; water; Yield given. Multistep reaction; 1.) acetonitrile; 2.) 30 min;

upstream raw materials:

4-Oxo-pentanoic acid (2R,3R,4R,5R)-3-hydroxy-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester

2,2,2,-tribromoethyl 2-chloro-4-tert-butylphenyl phosphorochloridate

N⁶-(4-methoxy-benzoyl)-O^2'-(4-methoxy-tetrahydro-pyran-4-yl)-adenosine

levulinic acid