Technology Process of C22H26N4O4
There total 1 articles about C22H26N4O4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-t-butyloxycarbonyl-DL-alanine; 2-aminopyridin-3-carboxylic acid;
With
4-methyl-morpholine; isobutyl chloroformate;
In
dichloromethane;
at -20 - 20 ℃;
for 20h;
4-methoxy-benzylamine;
In
dichloromethane;
at 20 ℃;
for 20h;
With
4-methyl-morpholine; isobutyl chloroformate;
In
dichloromethane;
at 20 ℃;
for 2h;
DOI:10.1002/cmdc.201200184
- Guidance literature:
-
Multi-step reaction with 4 steps
1: trifluoroacetic acid / dichloromethane
2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 h / 20 °C
3: 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 45 °C
4: ammonium cerium (IV) nitrate / water; acetonitrile / 20 h / 20 °C
With
ammonium cerium (IV) nitrate; 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/cmdc.201200184