7-methoxy-4-(3-methoxy-4-nitrophenoxy)quinoline

Base Information

• Chemical Name: 7-methoxy-4-(3-methoxy-4-nitrophenoxy)quinoline
• CAS No.: 1361235-65-5
• Molecular Formula: C₁₇H₁₄N₂O₅
• Molecular Weight: 326.309
• Mol file: 1361235-65-5.mol

Synonyms:

Chemical Property of 7-methoxy-4-(3-methoxy-4-nitrophenoxy)quinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-methoxy-4-(3-methoxy-4-nitrophenoxy)quinoline

There total 1 articles about 7-methoxy-4-(3-methoxy-4-nitrophenoxy)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

4-chloro-7-methoxyquinoline (68500-37-8) + 4-nitro-3-methoxyphenol (16292-95-8) → 7-methoxy-4-(3-methoxy-4-nitrophenoxy)quinoline (1361235-65-5)

Guidance literature:

In chlorobenzene; for 20h; Reflux; Inert atmosphere;

DOI:10.1021/jm201331s

Reference yield:

7-methoxy-4-(3-methoxy-4-nitrophenoxy)quinoline (1361235-65-5) → 2-methoxy-4-(7-methoxyquinolin-4-yloxy)aniline (1361235-66-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethyl acetate; at 20 ℃; for 20h;

DOI:10.1021/jm201331s

Reference yield:

7-methoxy-4-(3-methoxy-4-nitrophenoxy)quinoline (1361235-65-5) → N-(2-methoxy-4-(7-methoxyquinolin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (1361235-67-7)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / ethyl acetate / 20 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 60 °C / Inert atmosphere

With palladium on activated charcoal; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm201331s

upstream raw materials:

4-chloro-7-methoxyquinoline

4-nitro-3-methoxyphenol

Downstream raw materials:

2-methoxy-4-(7-methoxyquinolin-4-yloxy)aniline

N-(2-methoxy-4-(7-methoxyquinolin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Refernces