Methyl 1-ethyl-4-oxo-3-piperidinecarboxylate hydrochloride

Base Information

Chemical Name:Methyl 1-ethyl-4-oxo-3-piperidinecarboxylate hydrochloride
CAS No.:24318-88-5
Molecular Formula:C₉H₁₅NO₃
Molecular Weight:185.223
Hs Code.:
DSSTox Substance ID:DTXSID80701568
Mol file:24318-88-5.mol

Synonyms:24318-88-5;METHYL 1-ETHYL-4-OXO-3-PIPERIDINECARBOXYLATE HYDROCHLORIDE;24346-37-0;Methyl 1-ethyl-4-oxopiperidine-3-carboxylate hydrochloride;methyl 1-ethyl-4-oxopiperidine-3-carboxylate;hydrochloride;DTXSID80701568;MFCD09836251;AKOS022184919;Methyl1-ethyl-4-oxopiperidine-3-carboxylatehydrochloride;Methyl 1-ethyl-4-oxo-3-piperidinecarboxylate hydrochloride x1hcl;Methyl 1-ethyl-4-oxopiperidine-3-carboxylate--hydrogen chloride (1/1)

Suppliers and Price of Methyl 1-ethyl-4-oxo-3-piperidinecarboxylate hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
METHYL-1-ETHYL-4-OXO-3-PIPERIDINECARBOXYLATE HYDROCHLORIDE 95.00%
5MG
$ 503.40

Total 3 raw suppliers

Chemical Property of Methyl 1-ethyl-4-oxo-3-piperidinecarboxylate hydrochloride

Chemical Property:

Vapor Pressure:0.00603mmHg at 25°C
Boiling Point:272.6±35.0 °C(Predicted)
PKA:11.68±0.20(Predicted)
Density:1.094±0.06 g/cm3(Predicted)
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:221.0818711
Heavy Atom Count:14
Complexity:215

Purity/Quality:

97% ^*data from raw suppliers

METHYL-1-ETHYL-4-OXO-3-PIPERIDINECARBOXYLATE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1CCC(=O)C(C1)C(=O)OC.Cl

Technology Process of Methyl 1-ethyl-4-oxo-3-piperidinecarboxylate hydrochloride

There total 5 articles about Methyl 1-ethyl-4-oxo-3-piperidinecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3612-18-8
N-ethyl-4-piperidone

: 616-38-6
carbonic acid dimethyl ester

: 24318-88-5
1-ethyl-4-oxo-piperidine-3-carboxylic acid methyl ester

Guidance literature:: N-ethyl-4-piperidone; carbonic acid dimethyl ester; With sodium hydride; In tetrahydrofuran; for 6h; Inert atmosphere; Reflux;

With acetic acid; In tetrahydrofuran; water; Inert atmosphere; Cooling with ice;
DOI:10.1016/j.bioorg.2013.11.007

Reference yield:

: 41661-47-6
piperidin-4-one

: 24318-88-5
1-ethyl-4-oxo-piperidine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / dichloromethane / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 6 h / Inert atmosphere; Reflux

2.2: Inert atmosphere; Cooling with ice

With sodium hydride; potassium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bioorg.2013.11.007