3-Aminocyclobutanol hydrochloride

Base Information

• Chemical Name: 3-Aminocyclobutanol hydrochloride
• CAS No.: 1036260-25-9
• Molecular Formula: C4H9NO^.HCl
• Molecular Weight: 123.582
• Hs Code.: 2922199090
• European Community (EC) Number: 817-331-9,818-899-0,878-776-2
• Mol file: 1036260-25-9.mol

Synonyms:3-Aminocyclobutanol hydrochloride;TRANS-3-AMINOCYCLOBUTANOL HYDROCHLORIDE;CIS-3-AMINOCYCLOBUTANOL HYDROCHLORIDE;1219019-22-3;1036260-25-9;1205037-95-1;3-aminocyclobutan-1-ol hydrochloride;3-aminocyclobutan-1-ol;hydrochloride;cis-3-aminocyclobutanol HCl;trans-3-Aminocyclobutanol...;cis-3-Aminocyclobutanol h...;3-AMINOCYCLOBUTANOL HCL;MFCD12547215;TRANS-3-AMINOCYCLOBUTANOL HCL;(1s,3s)-3-aminocyclobutan-1-ol hydrochloride;MFCD17214231;MFCD17214232;(1s,3s)-3-aminocyclobutanol hydrochloride;cis-3-Aminocyclobutan-1-ol HCl;trans-3-Aminocyclobutan-1-ol HCl;MFCD09029039;SCHEMBL3097687;SCHEMBL3097692;SCHEMBL9985278;XUMSHCRPQCZRGX-AXMBXGHFSA-N;XUMSHCRPQCZRGX-HKTIBRIUSA-N;XUMSHCRPQCZRGX-UHFFFAOYSA-N;AMY11818;BCP32410;BCP32411;3-amino-1-cyclobutanol hydrochloride;AKOS006362375;AKOS015949211;AKOS015950298;Cyclobutanol, 3-amino-, hydrochloride;CS-W003832;CS-W022615;CS-W023030;DM-0788;DS-0945;PB11282;PB19576;SB10282;3-Aminocyclobutanol hydrochloride (1:1);DS-16925;SY025077;SY035914;SY035915;CIS-3-AMINOCYCLOBUTANOLHYDROCHLORIDE;trans-3-aminocyclobutan-1-ol hydrochloride;AM20070560;FT-0684936;FT-0686260;(1r,3r)-3-aminocyclobutan-1-ol hydrochloride;EN300-100583;EN300-134359;EN300-307592;A800770;CIS-3-AMINOCYCLOBUTANOL HYDROCHLORIDE 9:1;J-511683;J-520080;J-525007;Cyclobutanol, 3-amino-, hydrochloride (1:1), cis-;Z1416282421;Z2588063519

Chemical Property of 3-Aminocyclobutanol hydrochloride

Chemical Property:

• PSA: 46.25000
• LogP: 0.97070
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 123.0450916
• Heavy Atom Count: 7
• Complexity: 49.5

Purity/Quality:

98%, ^*data from raw suppliers

3-AminocyclobutanolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(CC1O)N.Cl
• Uses: 3-Aminocyclobutanol Hydrochloride is used as a reactant in the preparation of pyrrolopyrazine derivatives as selective spleen tyrosine kinase inhibitors.

Technology Process of 3-Aminocyclobutanol hydrochloride

There total 1 articles about 3-Aminocyclobutanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl ((1s,3s)-3-hydroxycyclobutyl)carbamate (154748-63-7) → 3-aminocyclobutan-1-ol hydrogen chloride (1036260-25-9)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 16h;

Reference yield: 99.0%

3-aminocyclobutan-1-ol hydrogen chloride (1036260-25-9) + 6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine-3-carboxylic acid (1365214-89-6) → 6-(2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(3-hydroxycyclobutyl)imidazo[1,2-b]pyridazine-3-carboxamide

Guidance literature:

6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine-3-carboxylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h; Inert atmosphere;

3-aminocyclobutan-1-ol hydrogen chloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c5md00388a

Reference yield: 62.6%

phthalic anhydride (85-44-9) + 3-aminocyclobutan-1-ol hydrogen chloride (1036260-25-9) → 2-(3-hydroxycyclobutyl)-2,3-dihydro-1H-isoindole-1,3-dione

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In toluene; at 110 ℃; for 18h;

upstream raw materials:

tert-butyl ((1s,3s)-3-hydroxycyclobutyl)carbamate

Refernces