Carbamic acid, (3-hydroxycyclobutyl)-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, (3-hydroxycyclobutyl)-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 154748-63-7
• Molecular Formula: C9H17NO3
• Molecular Weight: 187.239
• Hs Code.: 2924299090
• Mol file: 154748-63-7.mol

Synonyms:Carbamicacid, (3-hydroxycyclobutyl)-, 1,1-dimethylethyl ester (9CI);(3-Hydroxycyclobutyl)carbamic acid tert-butyl ester;tert-Butyl (3-hydroxycyclobutyl)carbamate;

Chemical Property of Carbamic acid, (3-hydroxycyclobutyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• Boiling Point: 303.672 °C at 760 mmHg
• PKA: 12.19±0.40(Predicted)
• Flash Point: 137.456 °C
• PSA: 58.56000
• Density: 1.107 g/cm³
• LogP: 1.42530
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl(3-hydroxycyclobutyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (3-hydroxycyclobutyl)-, 1,1-dimethylethyl ester (9CI)

There total 8 articles about Carbamic acid, (3-hydroxycyclobutyl)-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-(tert-butyloxycarbonylamino)cyclobutan-1-one (154748-49-9) → tert-butyl ((1s,3s)-3-hydroxycyclobutyl)carbamate (154748-63-7)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 - 25 ℃; for 1h;

Reference yield: 82.0%

tert-butyl (3-(benzyloxy)cyclobutyl)carbamate (154748-62-6) → tert-butyl ((1s,3s)-3-hydroxycyclobutyl)carbamate (154748-63-7)

Guidance literature:

With hydrogen; palladium dihydroxide; at 45 ℃; for 5h; under 33753.4 Torr;

Reference yield:

trans-3-[(tert-butoxycarbonyl)amino]cyclobutyl 4-nitrobenzoate (871014-16-3) → tert-butyl ((1s,3s)-3-hydroxycyclobutyl)carbamate (154748-63-7)

Guidance literature:

With potassium carbonate; In methanol; water; for 2h; Reflux;

upstream raw materials:

tert-butyl (3-(benzyloxy)cyclobutyl)carbamate

3-(tert-butyloxycarbonylamino)cyclobutan-1-one

(3-methylene-cyclobutyl)-carbamic acid tert-butyl ester

3-oxocyclobutanecarboxylic acid

Downstream raw materials:

3-((tert-butoxycarbonyl)amino)cyclobutyl 4-methylbenzenesulfonate

cis-3-[(tert-butoxycarbonyl)(methyl)amino]cyclobutyl methanesulfonate

tert-butyl (trans-3-aminocyclobutyl)methylcarbamate

tert-butyl 3-fluorocyclobutylcarbamate

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