N-(4-chlorobenzyl)(4-ethynylphenyl)methanamine

Base Information

• Chemical Name: N-(4-chlorobenzyl)(4-ethynylphenyl)methanamine
• CAS No.: 1049809-94-0
• Molecular Formula: C16H14ClN
• Molecular Weight: 255.747
• Mol file: 1049809-94-0.mol

Synonyms:N-(4-chlorobenzyl)(4-ethynylphenyl)methanamine;N-(4-chlorobenzyl)-1-(4-ethynylphenyl)methanamine

Chemical Property of N-(4-chlorobenzyl)(4-ethynylphenyl)methanamine

Chemical Property:

• PSA: 12.03000
• LogP: 4.00200
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

N-(4-Chlorobenzyl)-1-(4-ethynylphenyl)methanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-chlorobenzyl)(4-ethynylphenyl)methanamine

There total 3 articles about N-(4-chlorobenzyl)(4-ethynylphenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-[(trimethylsilyl)ethynyl]bezaldehyde (77123-57-0) + 4-chlorobenzylamine (104-86-9) → (4-chloro-benzyl)-(4-ethynyl-benzyl)-amine (1049809-94-0)

Guidance literature:

4-[(trimethylsilyl)ethynyl]bezaldehyde; 4-chlorobenzylamine; In methanol; at 20 ℃;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;

DOI:10.1021/jo902650b

Reference yield: 85.0%

4-Ethynylbenzaldehyde (63697-96-1) + 4-chlorobenzylamine (104-86-9) → (4-chloro-benzyl)-(4-ethynyl-benzyl)-amine (1049809-94-0)

Guidance literature:

4-Ethynylbenzaldehyde; 4-chlorobenzylamine; With acetic acid; In dichloromethane; for 0.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; for 72h; Product distribution / selectivity;

Reference yield:

4-Ethynylbenzaldehyde (63697-96-1) + 4-chlorobenzylamine (104-86-9) → (4-chloro-benzyl)-(4-ethynyl-benzyl)-amine (1049809-94-0) + C25H20ClN (1215171-58-6)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane;

DOI:10.1021/jo902650b

upstream raw materials:

4-Ethynylbenzaldehyde

4-chlorobenzylamine

4-[(trimethylsilyl)ethynyl]bezaldehyde

Downstream raw materials:

(S)-2-[3-(4-Chloro-3-{4-[(4-chloro-benzylamino)-methyl]-phenylethynyl}-phenyl)-1-(2-hydroxy-3-thiomorpholin-4-yl-propyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-acetamide

2-{3-(4-chloro-3-{4-[(4-chloro-benzylamino)-methyl]-phenylethynyl}-phenyl)-1-[3-(3-methyl-morpholin-4-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-2-oxo-acetamide L-tartrate

(4-Chloro-benzyl)-(4-{2-chloro-5-[5-methanesulfonyl-1-(3-morpholin-4-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-phenylethynyl}-benzyl)-amine

C₂₁H₂₂ClNO₂

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1049809-94-0 N-(4-chlorobenzyl)(4-ethynylphenyl)methanamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send