N-acetyl-L-tyrosyl-L-aspartoylbisoxy)hexyl>-L-alaninamide>

Base Information

• Chemical Name: N-acetyl-L-tyrosyl-L-aspartoylbisoxy)hexyl>-L-alaninamide>
• CAS No.: 129460-80-6
• Molecular Formula: C₄₅H₇₄N₆O₁₉
• Molecular Weight: 1003.11

Synonyms:

Chemical Property of N-acetyl-L-tyrosyl-L-aspartoylbisoxy)hexyl>-L-alaninamide>

Chemical Property:

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Technology Process of N-acetyl-L-tyrosyl-L-aspartoylbisoxy)hexyl>-L-alaninamide>

There total 9 articles about N-acetyl-L-tyrosyl-L-aspartoylbisoxy)hexyl>-L-alaninamide> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

6-aminohexyl-α-D-mannopyranoside (66888-26-4) + N-acetyl-L-tyrosyl-L-aspartoyldi-L-alanine (129460-85-1) → N-acetyl-L-tyrosyl-L-aspartoylbisoxy)hexyl>-L-alaninamide> (129460-80-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 24h;

DOI:10.1016/0008-6215(90)84295-6

Reference yield:

N-acetyl-L-tyrosine (537-55-3) → N-acetyl-L-tyrosyl-L-aspartoylbisoxy)hexyl>-L-alaninamide> (129460-80-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 63 percent / triethylamine, EEDQ / 24 h / Ambient temperature

2: H₂ / 10percent Pd-C / ethanol; aq. acetic acid / Ambient temperature

3: 67 percent / EDAC, HOBT / 10 h

4: 91 percent / H₂ / 10percent Pd-C / aq. ethanol; aq. acetic acid / 4 h / Ambient temperature

5: 63 percent / EDAC, HOBT / dimethylformamide / 24 h

With hydrogen; benzotriazol-1-ol; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In ethanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/0008-6215(90)84295-6

Reference yield:

N-acetyl-L-tyrosyl-L-aspartic acid (123126-84-1) → N-acetyl-L-tyrosyl-L-aspartoylbisoxy)hexyl>-L-alaninamide> (129460-80-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / EDAC, HOBT / 10 h

2: 91 percent / H₂ / 10percent Pd-C / aq. ethanol; aq. acetic acid / 4 h / Ambient temperature

3: 63 percent / EDAC, HOBT / dimethylformamide / 24 h

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/0008-6215(90)84295-6

upstream raw materials:

6-aminohexyl-α-D-mannopyranoside

N-acetyl-L-tyrosyl-L-aspartoyldi-L-alanine

6-(trifluoroacetamido)hexyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside

6-trifluoroacetamido-1-hexanol

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