ethyl 4-(2-chlorophenyl)thiazole-2-carboxylate

Base Information

• Chemical Name: ethyl 4-(2-chlorophenyl)thiazole-2-carboxylate
• CAS No.: 1050507-06-6
• Molecular Formula: C12H10 Cl N O2 S
• Molecular Weight: 267.736
• DSSTox Substance ID: DTXSID00699913
• Wikidata: Q82631004
• Mol file: 1050507-06-6.mol

Synonyms:1050507-06-6;ETHYL 4-(2-CHLOROPHENYL)THIAZOLE-2-CARBOXYLATE;ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate;2-Thiazolecarboxylicacid, 4-(2-chlorophenyl)-, ethyl ester;ethyl4-(2-chlorophenyl)thiazole-2-carboxylate;SCHEMBL13484523;4-(2-chlorophenyl)-2-Thiazolecarboxylic acid ethyl ester;DTXSID00699913;CS-M0675;AKOS010644216;CS-13695;FT-0731291

Chemical Property of ethyl 4-(2-chlorophenyl)thiazole-2-carboxylate

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 267.0120774
• Heavy Atom Count: 17
• Complexity: 277

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl4-(2-Chlorophenyl)thiazole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=NC(=CS1)C2=CC=CC=C2Cl

Technology Process of ethyl 4-(2-chlorophenyl)thiazole-2-carboxylate

There total 3 articles about ethyl 4-(2-chlorophenyl)thiazole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

ethyl Bromopyruvate (70-23-5) + 2-chlorothiobenzamide (15717-17-6) → ethyl 4-(2-chlorophenyl)thiazole-2-carboxylate (1050507-06-6) + ethyl 2-(2-chlorophenyl)thiazole-4-carboxylate (132089-36-2)

Guidance literature:

With pyridine; In ethanol; at 150 ℃; for 1.5h; Microwave irradiation;

DOI:10.1002/jhet.1644

Reference yield:

ethyl 2-amino-2-thioxoacetate (16982-21-1) + 2-chlorophenacyl bromide (5000-66-8) → ethyl 4-(2-chlorophenyl)thiazole-2-carboxylate (1050507-06-6)

Guidance literature:

In ethanol; for 6h; Heating / reflux;

Reference yield:

1-bromo-1-(2-chlorophenyl)acetone (65240-67-7) + ethyl 2-amino-2-sulfanylacetate → ethyl 4-(2-chlorophenyl)thiazole-2-carboxylate (1050507-06-6)

Guidance literature:

In ethanol; for 6h; Reflux;

upstream raw materials:

ethyl 2-amino-2-thioxoacetate

2-chlorophenacyl bromide

ethyl Bromopyruvate

2-chlorothiobenzamide

Downstream raw materials:

(4-(2-chlorophenyl)thiazol-2-yl)methanol

4-(2-chlorophenyl)thiazole-2-carboxylic acid

6-{[4-(2-chloro-phenyl)-thiazol-2-ylmethyl]-amino}-naphthalene-2-carboxylic acid

6-{[4-(2-chloro-phenyl)-thiazol-2-ylmethyl]-amino}-naphthalene-2-carboxylic acid methyl ester