Technology Process of 4-fluoro-N-(((6S,12R,13R)-15-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6,13-dimethyl-16-oxo-6,7,8,9,10,12,13,14,15,16-decahydropyrido[3,2-b][1,9,5]dioxaazacyclotetradecin-12-yl)methyl)-N-methylbenzenesulfonamide
There total 10 articles about 4-fluoro-N-(((6S,12R,13R)-15-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6,13-dimethyl-16-oxo-6,7,8,9,10,12,13,14,15,16-decahydropyrido[3,2-b][1,9,5]dioxaazacyclotetradecin-12-yl)methyl)-N-methylbenzenesulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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![4-fluoro-N-(((6S,12R,13R)-15-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6,13-dimethyl-16-oxo-6,7,8,9,10,12,13,14,15,16-decahydropyrido[3,2-b][1,9,5]dioxaazacyclotetradecin-12-yl)methyl)-N-methylbenzenesulfonamide](/Databaselist/images/loading.webp)
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1403478-94-3
4-fluoro-N-(((6S,12R,13R)-15-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6,13-dimethyl-16-oxo-6,7,8,9,10,12,13,14,15,16-decahydropyrido[3,2-b][1,9,5]dioxaazacyclotetradecin-12-yl)methyl)-N-methylbenzenesulfonamide
- Guidance literature:
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With
2,6-dimethylpyridine;
In
dichloromethane;
at 20 ℃;
Inert atmosphere;
DOI:10.1021/jm500994n
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1403478-94-3
4-fluoro-N-(((6S,12R,13R)-15-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6,13-dimethyl-16-oxo-6,7,8,9,10,12,13,14,15,16-decahydropyrido[3,2-b][1,9,5]dioxaazacyclotetradecin-12-yl)methyl)-N-methylbenzenesulfonamide
- Guidance literature:
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Multi-step reaction with 8 steps
1: N-ethyl-N,N-diisopropylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 0 - 20 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C
3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C
4: Hoveyda-Grubbs catalyst second generation / toluene / 20 °C / Inert atmosphere
5: hydrogen; palladium 10% on activated carbon / ethanol / 35 °C
6: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C
7: pyridine hydrogenfluoride / tetrahydrofuran / 20 °C
8: 2,6-dimethylpyridine / dichloromethane / 20 °C / Inert atmosphere
With
2,6-dimethylpyridine; Hoveyda-Grubbs catalyst second generation; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; pyridine hydrogenfluoride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm500994n
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1403478-94-3
4-fluoro-N-(((6S,12R,13R)-15-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6,13-dimethyl-16-oxo-6,7,8,9,10,12,13,14,15,16-decahydropyrido[3,2-b][1,9,5]dioxaazacyclotetradecin-12-yl)methyl)-N-methylbenzenesulfonamide
- Guidance literature:
-
Multi-step reaction with 8 steps
1: N-ethyl-N,N-diisopropylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 0 - 20 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C
3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C
4: Hoveyda-Grubbs catalyst second generation / toluene / 20 °C / Inert atmosphere
5: hydrogen; palladium 10% on activated carbon / ethanol / 35 °C
6: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C
7: pyridine hydrogenfluoride / tetrahydrofuran / 20 °C
8: 2,6-dimethylpyridine / dichloromethane / 20 °C / Inert atmosphere
With
2,6-dimethylpyridine; Hoveyda-Grubbs catalyst second generation; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; pyridine hydrogenfluoride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm500994n
