Acetic acid (S)-3-[2-[(1R,7aR)-1-((1R,5R)-6-acetoxy-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

Base Information

• Chemical Name: Acetic acid (S)-3-[2-[(1R,7aR)-1-((1R,5R)-6-acetoxy-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester
• CAS No.: 88099-49-4
• Molecular Formula: C₃₁H₄₈O₅
• Molecular Weight: 500.719

Synonyms:

Chemical Property of Acetic acid (S)-3-[2-[(1R,7aR)-1-((1R,5R)-6-acetoxy-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (S)-3-[2-[(1R,7aR)-1-((1R,5R)-6-acetoxy-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

There total 30 articles about Acetic acid (S)-3-[2-[(1R,7aR)-1-((1R,5R)-6-acetoxy-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3β-hydroxy-5-cholenoic acid (5255-17-4) → (25S)-25,26-dihydroxyvitamin D3 3β,26-diacetate (88099-49-4)

Guidance literature:

Multi-step reaction with 13 steps

1: 1.) toluene-p-sulphonic acid, 2.) lithium aluminium hydride / 1.) benzene, room temperature, 2 h, 2.) THF, room temperature, 1 h

2: 3.26 g / pyridinium chlorochromate / CH₂Cl₂ / 3 h / Ambient temperature

3: 1.4 g / tetrahydrofuran / 3 h / Ambient temperature

4: 115.4 mg / pyridinium dichromate / CH₂Cl₂; dimethylformamide / 2 h / Ambient temperature

5: 36.4 mg / lithium aluminium hydride, ethanol, (R)-(+)-2,2'-dihydroxy-1,1'-binaphthyl / tetrahydrofuran / 20 h / -90 °C

6: 47.8 mg / t-butyl hydroperoxide, VO(acac)2 / benzene / 3 h / Ambient temperature

7: 21 mg / potassium carbonate / propan-2-ol / 2 h / Heating

8: 367 mg / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating

9: 215 mg / 2M-aq. hydrochloric acid / methanol / 1 h / Ambient temperature

10: 48 mg / pyridine / 18 h / Ambient temperature

11: N-bromosuccinimide / CCl₄ / 0.33 h / Heating

12: 1.) s-collidine, 2.) toluene-p-sulphonic acid / 1.) xylene, reflux, 10 min, 2.) acetone, RT, 15 h

13: 3.69 mg / benzene; ethanol / 1.) irradiation, ice-cooling, 2.5 min, 2.) reflux, 1 h

With pyridine; 2,4,6-trimethyl-pyridine; hydrogenchloride; tert.-butylhydroperoxide; N-Bromosuccinimide; lithium aluminium tetrahydride; dipyridinium dichromate; bis(acetylacetonate)oxovanadium; ethanol; (R)-1,1'-Bi-2-naphthol; potassium carbonate; toluene-4-sulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; benzene;

Reference yield:

3β-hydroxy-5-cholenoic acid (5255-17-4) → Acetic acid (S)-3-[2-[(1R,7aR)-1-((1R,5R)-6-acetoxy-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester (88099-49-4)

Guidance literature:

Multi-step reaction with 13 steps

1: 1.) toluene-p-sulphonic acid, 2.) lithium aluminium hydride / 1.) benzene, room temperature, 2 h, 2.) THF, room temperature, 1 h

2: 3.26 g / pyridinium chlorochromate / CH₂Cl₂ / 3 h / Ambient temperature

3: 1.4 g / tetrahydrofuran / 3 h / Ambient temperature

4: 115.4 mg / pyridinium dichromate / CH₂Cl₂; dimethylformamide / 2 h / Ambient temperature

5: 36.4 mg / lithium aluminium hydride, ethanol, (R)-(+)-2,2'-dihydroxy-1,1'-binaphthyl / tetrahydrofuran / 20 h / -90 °C

6: 47.8 mg / t-butyl hydroperoxide, VO(acac)2 / benzene / 3 h / Ambient temperature

7: 21 mg / potassium carbonate / propan-2-ol / 2 h / Heating

8: 367 mg / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating

9: 306 mg / 2M-aq. hydrochloric acid / methanol / Ambient temperature

10: 185 mg / pyridine / Ambient temperature

11: N-bromosuccinimide / CCl₄ / Heating

12: 1.) s-collidine, 2.) toluene-p-sulphonic acid / 1.) xylene, reflux, 2.) acetone, RT

13: benzene; ethanol / 1.) irradiation, ice-cooling, 2.) reflux

With pyridine; 2,4,6-trimethyl-pyridine; hydrogenchloride; tert.-butylhydroperoxide; N-Bromosuccinimide; lithium aluminium tetrahydride; dipyridinium dichromate; bis(acetylacetonate)oxovanadium; ethanol; (R)-1,1'-Bi-2-naphthol; potassium carbonate; toluene-4-sulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; benzene;

Reference yield:

3β-(tetrahydro-2H-pyran-2-yloxy)chol-5-en-24-ol (66414-43-5) → (25S)-25,26-dihydroxyvitamin D3 3β,26-diacetate (88099-49-4)

Guidance literature:

Multi-step reaction with 12 steps

1: 3.26 g / pyridinium chlorochromate / CH₂Cl₂ / 3 h / Ambient temperature

2: 1.4 g / tetrahydrofuran / 3 h / Ambient temperature

3: 115.4 mg / pyridinium dichromate / CH₂Cl₂; dimethylformamide / 2 h / Ambient temperature

4: 36.4 mg / lithium aluminium hydride, ethanol, (R)-(+)-2,2'-dihydroxy-1,1'-binaphthyl / tetrahydrofuran / 20 h / -90 °C

5: 47.8 mg / t-butyl hydroperoxide, VO(acac)2 / benzene / 3 h / Ambient temperature

6: 21 mg / potassium carbonate / propan-2-ol / 2 h / Heating

7: 367 mg / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating

8: 215 mg / 2M-aq. hydrochloric acid / methanol / 1 h / Ambient temperature

9: 48 mg / pyridine / 18 h / Ambient temperature

10: N-bromosuccinimide / CCl₄ / 0.33 h / Heating

11: 1.) s-collidine, 2.) toluene-p-sulphonic acid / 1.) xylene, reflux, 10 min, 2.) acetone, RT, 15 h

12: 3.69 mg / benzene; ethanol / 1.) irradiation, ice-cooling, 2.5 min, 2.) reflux, 1 h

With pyridine; 2,4,6-trimethyl-pyridine; hydrogenchloride; tert.-butylhydroperoxide; N-Bromosuccinimide; lithium aluminium tetrahydride; dipyridinium dichromate; bis(acetylacetonate)oxovanadium; ethanol; (R)-1,1'-Bi-2-naphthol; potassium carbonate; toluene-4-sulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; benzene;

upstream raw materials:

(25S)-3β,26-diacetoxy-25-hydroxycholesta-5,7-diene

3β-hydroxy-5-cholenoic acid

3β-(tetrahydro-2H-pyran-2-yloxy)chol-5-en-24-ol

3β-(tetrahydro-2H-pyran-2-yloxy)chol-5-en-24-al

Downstream raw materials:

(25S)-25,26-dihydroxyvitamin D₃

(25R)-25,26-dihydroxyvitamin D₃

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 88099-49-4 Acetic acid (S)-3-[2-[(1R,7aR)-1-((1R,5R)-6-acetoxy-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send