ethyl 6-fluoro-1-hydroxy-2-naphthoate

Base Information

Chemical Name:ethyl 6-fluoro-1-hydroxy-2-naphthoate
CAS No.:1350662-98-4
Molecular Formula:C₁₃H₁₁FO₃
Molecular Weight:234.227
Hs Code.:

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Chemical Property of ethyl 6-fluoro-1-hydroxy-2-naphthoate

Chemical Property:

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Technology Process of ethyl 6-fluoro-1-hydroxy-2-naphthoate

There total 5 articles about ethyl 6-fluoro-1-hydroxy-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: C₁₃H₁₃FO₃

: 1350662-98-4
ethyl 6-fluoro-1-hydroxy-2-naphthoate

: 1350663-09-0
ethyl 6-fluoro-2-hydroxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Guidance literature:: With 5-trimethylammonio-1,3-dioxo-1,3-dihydro-1λ⁵-benzo[d][1,2]-iodoxol-1-ol anion; water; In diethylene glycol dimethyl ether; at 60 ℃; for 22h;
DOI:10.1021/ol202777h

Reference yield:

: 703-67-3
6-fluoro-3,4-dihydronaphthalen-1(2H)-one

: 1350662-98-4
ethyl 6-fluoro-1-hydroxy-2-naphthoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / Reflux

2: 5-trimethylammonio-1,3-dioxo-1,3-dihydro-1λ⁵-benzo[d][1,2]-iodoxol-1-ol anion; water / diethylene glycol dimethyl ether / 22 h / 60 °C

With 5-trimethylammonio-1,3-dioxo-1,3-dihydro-1λ⁵-benzo[d][1,2]-iodoxol-1-ol anion; water; sodium hydride; In diethylene glycol dimethyl ether;
DOI:10.1021/ol202777h

Reference yield:

: 3470-50-6
6-Hydroxy-1-tetralone

: 1350662-98-4
ethyl 6-fluoro-1-hydroxy-2-naphthoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2-bromo-2-methylpropanamide; sodium hydroxide / N,N-dimethyl acetamide / 5 h / 20 °C

1.2: 1 h / 50 °C

2.1: hydrogenchloride; sodium tetrafluoroborate; sodium nitrite

3.1: sodium hydride / Reflux

4.1: 5-trimethylammonio-1,3-dioxo-1,3-dihydro-1λ⁵-benzo[d][1,2]-iodoxol-1-ol anion; water / diethylene glycol dimethyl ether / 22 h / 60 °C

With hydrogenchloride; sodium tetrafluoroborate; 2-bromo-2-methylpropanamide; 5-trimethylammonio-1,3-dioxo-1,3-dihydro-1λ⁵-benzo[d][1,2]-iodoxol-1-ol anion; water; sodium hydride; sodium hydroxide; sodium nitrite; In diethylene glycol dimethyl ether; N,N-dimethyl acetamide;
DOI:10.1021/ol202777h