3-chloro-5H-pyrrolo[2,3-b]pyrazine

Base Information

• Chemical Name: 3-chloro-5H-pyrrolo[2,3-b]pyrazine
• CAS No.: 1111638-10-8
• Molecular Formula: C6H4ClN3
• Molecular Weight: 153.57
• Hs Code.: 2933998090
• Mol file: 1111638-10-8.mol

Synonyms:5H-pyrrolo[2,3-b]pyrazine, 2-chloro-;

Chemical Property of 3-chloro-5H-pyrrolo[2,3-b]pyrazine

Chemical Property:

• PKA: 10?+-.0.50(Predicted)
• PSA: 41.57000
• Density: 1.531 g/cm³
• LogP: 1.61130
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Chloro-5H-pyrrolo[2,3-b]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Chloro-5H-pyrrolo[2,3-b]pyrazine is used in the preparation of pyrazole compounds as Raf inhibitors.

Technology Process of 3-chloro-5H-pyrrolo[2,3-b]pyrazine

There total 3 articles about 3-chloro-5H-pyrrolo[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-chloro-3-((trimethylsilyl)ethynyl)pyrazin-2-amine (1111638-09-5) → 3-chloro-5H-pyrrolo[2,3-b]pyrazine (1111638-10-8)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 - 75 ℃; for 3h;

DOI:10.1021/acs.jmedchem.8b01725

Reference yield: 67.0%

6-chloro-3-ethynylpyrazin-2-amine → 3-chloro-5H-pyrrolo[2,3-b]pyrazine (1111638-10-8)

Guidance literature:

With potassium tert-butylate; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 16h;

Reference yield: 63.0%

6-chloro-3-((trimethylsilyl)ethynyl)pyrazin-2-amine (1111638-09-5) + potassium tert-butylate (865-47-4) + tert-butyl alcohol (75-65-0) → 3-chloro-5H-pyrrolo[2,3-b]pyrazine (1111638-10-8)

Guidance literature:

6-chloro-3-((trimethylsilyl)ethynyl)pyrazin-2-amine; potassium tert-butylate; tert-butyl alcohol; at 80 ℃;

With hydrogenchloride; water; In tert-butyl alcohol; at 80 ℃;

With water; sodium carbonate; In ethyl acetate; tert-butyl alcohol;

upstream raw materials:

6-chloro-3-((trimethylsilyl)ethynyl)pyrazin-2-amine

potassium tert-butylate

tert-butyl alcohol

Downstream raw materials:

3-chloro-5-methyl-5H-pyrrolo[2,3-b]pyrazine

2-(3-{5-chloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine-3-yl}-5H-pyrrolo[2,3-b]pyrazin-5-yl)-N-(2,2,2-trifluoroethyl)acetamide