Technology Process of (3aS,6R,7S,7aS)-6,7-Bis-benzyloxy-5-benzyloxymethyl-3-(4-methoxy-benzyl)-3a,6,7,7a-tetrahydro-3H-benzooxazol-2-one
There total 16 articles about (3aS,6R,7S,7aS)-6,7-Bis-benzyloxy-5-benzyloxymethyl-3-(4-methoxy-benzyl)-3a,6,7,7a-tetrahydro-3H-benzooxazol-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 14 steps
1: 1) NaH, HMPA / THF
2: m-CPBA / CH2Cl2 / -10 °C
3: Sharpless-Reich reaction
4: m-CPBA / CH2Cl2 / 0 °C
5: 1) NaH, HMPA / THF
6: Sharpless-Reich reaction
7: DEAD, PPh3
8: KOH, aq. EtOH / tetrahydrofuran
9: KH / tetrahydrofuran
12: 1) I2, sieves, 2) aq. Na2SO3 / 1) THF
13: m-CPBA / CH2Cl2 / 60 h / -10 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; molecular sieve; ethanol; iodine; potassium hydride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; sodium sulfite; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)91850-1
- Guidance literature:
-
Multi-step reaction with 14 steps
1: 1) NaH, HMPA / THF
2: m-CPBA / CH2Cl2 / -10 °C
3: Sharpless-Reich reaction
4: m-CPBA / CH2Cl2 / 0 °C
5: 1) NaH, HMPA / THF
6: Sharpless-Reich reaction
7: DEAD, PPh3
8: KOH, aq. EtOH / tetrahydrofuran
9: KH / tetrahydrofuran
12: 1) I2, sieves, 2) aq. Na2SO3 / 1) THF
13: m-CPBA / CH2Cl2 / 60 h / -10 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; molecular sieve; ethanol; iodine; potassium hydride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; sodium sulfite; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)91850-1
- Guidance literature:
-
Multi-step reaction with 13 steps
1: m-CPBA / CH2Cl2 / -10 °C
2: Sharpless-Reich reaction
3: m-CPBA / CH2Cl2 / 0 °C
4: 1) NaH, HMPA / THF
5: Sharpless-Reich reaction
6: DEAD, PPh3
7: KOH, aq. EtOH / tetrahydrofuran
8: KH / tetrahydrofuran
11: 1) I2, sieves, 2) aq. Na2SO3 / 1) THF
12: m-CPBA / CH2Cl2 / 60 h / -10 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; molecular sieve; ethanol; iodine; potassium hydride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; sodium sulfite; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)91850-1
