5-bromo-3-iodo-4-methylpyridin-2-amine

Base Information

Chemical Name:5-bromo-3-iodo-4-methylpyridin-2-amine
CAS No.:1150618-04-4
Molecular Formula:C6H6BrIN2
Molecular Weight:312.936
Hs Code.:
Mol file:1150618-04-4.mol

Synonyms:5-bromo-3-iodo-4-methyl-2-pyridinamine;5-bromo-3-iodo-4-methyl-pyridin-2-ylamine;2-Pyridinamine,5-bromo-3-iodo-4-methyl;

Suppliers and Price of 5-bromo-3-iodo-4-methylpyridin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Bromo-3-iodo-4-methylpyridin-2-amine
250mg
$ 265.00

Crysdot
5-Bromo-3-iodo-4-methylpyridin-2-amine 95+%
10g
$ 2036.00

Crysdot
5-Bromo-3-iodo-4-methylpyridin-2-amine 95+%
5g
$ 1358.00

Chemenu
2-Amino-5-bromo-3-iodo-4-methylpyridine 95%
5g
$ 804.00

American Custom Chemicals Corporation
5-BROMO-3-IODO-4-METHYL-2-PYRIDINAMINE 95.00%
5G
$ 909.56

Alichem
5-Bromo-3-iodo-4-methylpyridin-2-amine
10g
$ 2154.60

Alichem
5-Bromo-3-iodo-4-methylpyridin-2-amine
5g
$ 1450.08

AK Scientific
5-Bromo-3-iodo-4-methylpyridin-2-amine
5g
$ 998.00

Total 16 raw suppliers

Chemical Property of 5-bromo-3-iodo-4-methylpyridin-2-amine

Chemical Property:

Boiling Point:316℃
PKA:2.88±0.50(Predicted)
Flash Point:145℃
PSA：39.64000
Density:2.243
LogP:2.26940
Storage Temp.:2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-3-iodo-4-methylpyridin-2-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-bromo-3-iodo-4-methylpyridin-2-amine

There total 1 articles about 5-bromo-3-iodo-4-methylpyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 98198-48-2
2-amino-5-bromo-4-methylpyridine

: 1150618-04-4
5-bromo-3-iodo-4-methyl-pyridin-2-ylamine

Guidance literature:: With N-iodo-succinimide; trifluoroacetic acid; In N,N-dimethyl-formamide; at 55 ℃; for 2h;

Reference yield: 85.0%

: 1150618-04-4
5-bromo-3-iodo-4-methyl-pyridin-2-ylamine

: 1066-54-2
trimethylsilylacetylene

: 1326216-30-1
5-bromo-4-methyl-3-((trimethylsilyl)ethynyl)pyridin-2-amine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1021/acs.jmedchem.1c00674

Reference yield:

: 1150618-04-4
5-bromo-3-iodo-4-methyl-pyridin-2-ylamine

: {3-[6-[2-(4-cyano-phenyl)-2H-pyrazol-3-yl]-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylcarbamoyloxy]-propyl}-trimethyl-ammonium chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; methanol; ethanol / 2 h / Reflux

2.1: 1,4-dioxane / 18 h / 20 °C

2.2: 4.5 h / 60 °C

3.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 27.5 h / 75 °C / Reflux

4.1: pyridine / tetrahydrofuran / 0.67 h / 20 - 60 °C / Microwave irradiation

5.1: ethanol; acetonitrile / 1.33 h / 100 °C / Microwave irradiation

With pyridine; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; toluene; acetonitrile;