[7-Chloro-5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-(2Z)-ylidene]-(2-chloro-propionylamino)-acetic acid methyl ester

Base Information

• Chemical Name: [7-Chloro-5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-(2Z)-ylidene]-(2-chloro-propionylamino)-acetic acid methyl ester
• CAS No.: 87216-21-5
• Molecular Formula: C₂₁H₁₈Cl₃N₃O₃
• Molecular Weight: 466.751
• Mol file: 87216-21-5.mol

Synonyms:

Chemical Property of [7-Chloro-5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-(2Z)-ylidene]-(2-chloro-propionylamino)-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [7-Chloro-5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-(2Z)-ylidene]-(2-chloro-propionylamino)-acetic acid methyl ester

There total 1 articles about [7-Chloro-5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-(2Z)-ylidene]-(2-chloro-propionylamino)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloropropionyl chloride (7623-09-8) + α-amino-7-chloro-5-(2-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene acetic acid methyl ester ethanolate → [7-Chloro-5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-(2Z)-ylidene]-(2-chloro-propionylamino)-acetic acid methyl ester (87216-21-5)

Guidance literature:

In dichloromethane; for 0.0833333h; Heating;

DOI:10.1002/jhet.5570200357

Reference yield:

[7-Chloro-5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-(2Z)-ylidene]-(2-chloro-propionylamino)-acetic acid methyl ester (87216-21-5) → 9-chloro-7-(2-chlorophenyl)-1-methyl-2-oxo-1,2,3,5-tetrahydropyrazino<1,2-a><1,4>-benzodiazepine-4-carboxylic acid methyl ester (87216-20-4)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 2h; Yield given; Heating;

DOI:10.1002/jhet.5570200357

upstream raw materials:

2-chloropropionyl chloride

Downstream raw materials:

9-chloro-7-(2-chlorophenyl)-1-methyl-2-oxo-1,2,3,5-tetrahydropyrazino<1,2-a><1,4>-benzodiazepine-4-carboxylic acid methyl ester