Technology Process of (2R,3R)-3-O-benzoyl-1,2-isopropylidenebutane-1,2,3-triol
There total 5 articles about (2R,3R)-3-O-benzoyl-1,2-isopropylidenebutane-1,2,3-triol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) 30percent H2O2, K2CO3 / 1.) water, overnight, 2.) acetonitrile, reflux, 24 h
2: 95.3 percent / lithium aluminum hydride / tetrahydrofuran / a) 1 h, b) reflux, 1 h
3: 79.5 percent / diethyl azodicarboxylate (DEAD), triphenylphosphine (TPP) / benzene
4: 82.5 percent / LAH / diethyl ether / a) RT, 2h, b) reflux, 1 h
5: triphenylphosphate (TPP), diisopropyl azodicarboxylate (DIAD) / benzene / 20 h / Ambient temperature
With
lithium aluminium tetrahydride; phosphoric acid triphenyl ester; di-isopropyl azodicarboxylate; dihydrogen peroxide; potassium carbonate; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; diethyl ether; benzene;
DOI:10.1021/jo00246a037
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 79.5 percent / diethyl azodicarboxylate (DEAD), triphenylphosphine (TPP) / benzene
2: 82.5 percent / LAH / diethyl ether / a) RT, 2h, b) reflux, 1 h
3: triphenylphosphate (TPP), diisopropyl azodicarboxylate (DIAD) / benzene / 20 h / Ambient temperature
With
lithium aluminium tetrahydride; phosphoric acid triphenyl ester; di-isopropyl azodicarboxylate; triphenylphosphine; diethylazodicarboxylate;
In
diethyl ether; benzene;
DOI:10.1021/jo00246a037
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 95.3 percent / lithium aluminum hydride / tetrahydrofuran / a) 1 h, b) reflux, 1 h
2: 79.5 percent / diethyl azodicarboxylate (DEAD), triphenylphosphine (TPP) / benzene
3: 82.5 percent / LAH / diethyl ether / a) RT, 2h, b) reflux, 1 h
4: triphenylphosphate (TPP), diisopropyl azodicarboxylate (DIAD) / benzene / 20 h / Ambient temperature
With
lithium aluminium tetrahydride; phosphoric acid triphenyl ester; di-isopropyl azodicarboxylate; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; diethyl ether; benzene;
DOI:10.1021/jo00246a037