4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine

Base Information

• Chemical Name: 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine
• CAS No.: 1000303-67-2
• Molecular Formula: C6H8 N2 O
• Molecular Weight: 124.14100
• Mol file: 1000303-67-2.mol

Synonyms:

Chemical Property of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine

Chemical Property:

• Boiling Point: 262℃
• PKA: 7.79±0.20(Predicted)
• Flash Point: 112℃
• PSA: 38.06000
• Density: 1.146
• LogP: 0.64910

Purity/Quality:

98%min ^*data from raw suppliers

4,5,6,7-Tetrahydroisoxazolo[4,3-c]pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine

There total 3 articles about 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

tert-butyl 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-5-carboxylate → 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine (1000303-67-2)

Guidance literature:

With methanol; acetyl chloride; at 0 - 23 ℃; for 16h;

DOI:10.1002/ejoc.201301039

Reference yield:

3-[N-(tert-butyloxycarbonyl)-N-propargylamino]propanal → 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine (1000303-67-2)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium hydroxide / water; ethanol / 4 h / 23 °C / Cooling with ice

2: chloroamine-T / acetonitrile / 16 h / 85 °C

3: acetyl chloride; methanol / 16 h / 0 - 23 °C

With methanol; hydroxylamine hydrochloride; chloroamine-T; acetyl chloride; sodium hydroxide; In ethanol; water; acetonitrile;

DOI:10.1002/ejoc.201301039

Reference yield:

3-[N-(tert-butyloxycarbonyl)-N-propargylamino]propanal oxime → 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine (1000303-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1: chloroamine-T / acetonitrile / 16 h / 85 °C

2: acetyl chloride; methanol / 16 h / 0 - 23 °C

With methanol; chloroamine-T; acetyl chloride; In acetonitrile;

DOI:10.1002/ejoc.201301039

Downstream raw materials:

5-benzyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine

Refernces