5-benzyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine

Base Information

• Chemical Name: 5-benzyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine
• CAS No.: 35005-72-2
• Molecular Formula: C13H14N2O
• Molecular Weight: 214.26
• Mol file: 35005-72-2.mol

Synonyms:5-Benzyl-4,5,6,7-tetrahydro-isoxazolo[4,3-c]pyridine;5-Benzyl-4,5,6,7-tetrahydroisoxazolo-<4,3-c>pyridin;

Chemical Property of 5-benzyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine

Chemical Property:

• Melting Point: 78 - 79 °C
• PSA: 29.27000
• LogP: 2.17080

Purity/Quality:

99% ^*data from raw suppliers

5-Benzyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-benzyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine

There total 5 articles about 5-benzyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine (1000303-67-2) + benzaldehyde (100-52-7) → 5-benzyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine (35005-72-2)

Guidance literature:

4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine; benzaldehyde; In methanol; at 0 ℃; for 1h;

With sodium cyanoborohydride; zinc(II) chloride; In methanol; at 0 - 23 ℃; for 2h;

DOI:10.1002/ejoc.201301039

Reference yield:

3-[N-(tert-butyloxycarbonyl)-N-propargylamino]propanal → 5-benzyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine (35005-72-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium hydroxide / water; ethanol / 4 h / 23 °C / Cooling with ice

2.1: chloroamine-T / acetonitrile / 16 h / 85 °C

3.1: acetyl chloride; methanol / 16 h / 0 - 23 °C

4.1: methanol / 1 h / 0 °C

4.2: 2 h / 0 - 23 °C

With methanol; hydroxylamine hydrochloride; chloroamine-T; acetyl chloride; sodium hydroxide; In methanol; ethanol; water; acetonitrile;

DOI:10.1002/ejoc.201301039

Reference yield:

3-[N-(tert-butyloxycarbonyl)-N-propargylamino]propanal oxime → 5-benzyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine (35005-72-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: chloroamine-T / acetonitrile / 16 h / 85 °C

2.1: acetyl chloride; methanol / 16 h / 0 - 23 °C

3.1: methanol / 1 h / 0 °C

3.2: 2 h / 0 - 23 °C

With methanol; chloroamine-T; acetyl chloride; In methanol; acetonitrile;

DOI:10.1002/ejoc.201301039

upstream raw materials:

4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine

benzaldehyde

Refernces

• 1、 Schenone,Mosti,Bignardi. "Derivatives of 1-substituted 2,3-dihydro-3-hydroxymethylene-4-quinolones and of 1-benzyl-3-hydroxymethylene-4-piperidone". . p. 857 - 867. Retrieved 2007/10/08.