N-Benzyl-1-phenoxypropan-2-amine

Base Information

• Chemical Name: N-Benzyl-1-phenoxypropan-2-amine
• CAS No.: 59182-23-9
• Molecular Formula: C₁₆H₁₉NO
• Molecular Weight: 241.333
• UNII: QD6HJ75MCJ

Synonyms:N-Benzyl-1-phenoxypropan-2-amine;59182-23-9;N-(1-Methyl-2-phenoxyethyl)benzylamine;N-(1-Methyl-2-phenoxyethyl)benzenemethanamine;QD6HJ75MCJ;Benzenemethanamine, N-(1-methyl-2-phenoxyethyl)-;starbld0007725;UNII-QD6HJ75MCJ

Chemical Property of N-Benzyl-1-phenoxypropan-2-amine

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 241.146664230
• Heavy Atom Count: 18
• Complexity: 207

Purity/Quality:

98%2H ^*data from raw suppliers

N-(1-Methyl-2-phenoxyethyl)benzylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(COC1=CC=CC=C1)NCC2=CC=CC=C2
• Uses: N-(1-Methyl-2-phenoxyethyl)benzylamine is used as a reagent to synthesize benzenesulfonamide derivatives with α- and β-adrenergic antagonistic and antihypertensive activities.

Technology Process of N-Benzyl-1-phenoxypropan-2-amine

There total 2 articles about N-Benzyl-1-phenoxypropan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-phenoxy-2-propanone (621-87-4) + benzylamine (100-46-9) → N-benzyl-1-methyl-2-phenoxy ethylamine (59182-23-9)

Guidance literature:

With ethanol; anschliessendes Hydrieren an Platin;

Reference yield:

→ N-benzyl-1-methyl-2-phenoxy ethylamine (59182-23-9)

Guidance literature:

aus (+-)-Benzyl-<β-chlor-isopropyl>-amin (4c) (analog den Enantiomeren 6a und 6b);

DOI:10.1021/jm00289a001

Reference yield:

2-bromo-1-[3-[(methylsulfonyl)amino]phenyl]ethanone (2065-04-5) + N-benzyl-1-methyl-2-phenoxy ethylamine (59182-23-9) → N-(3-{2-[Benzyl-(1-methyl-2-phenoxy-ethyl)-amino]-acetyl}-phenyl)-methanesulfonamide

Guidance literature:

In acetonitrile;

DOI:10.1021/jm00319a023

upstream raw materials:

3-phenoxy-2-propanone

benzylamine

Downstream raw materials:

5-{2-[Benzyl-(1-methyl-2-phenoxy-ethyl)-amino]-acetyl}-2-methyl-benzenesulfonamide

5-{2-[Benzyl-(1-methyl-2-phenoxy-ethyl)-amino]-acetyl}-2-methoxy-benzenesulfonamide

5-{2-[Benzyl-(1-methyl-2-phenoxy-ethyl)-amino]-acetyl}-2-hydroxy-benzenesulfonamide

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