3-Quinolinecarbonitrile, 7-fluoro-1,4-dihydro-4-oxo-

Base Information

Chemical Name:3-Quinolinecarbonitrile, 7-fluoro-1,4-dihydro-4-oxo-
CAS No.:1008780-80-0
Molecular Formula:C₁₀H₅FN₂O
Molecular Weight:188.161
Hs Code.:
Mol file:1008780-80-0.mol

Synonyms:7-fluoro-4-hydroxyquinoline-3-carbonitrile;3-Quinolinecarbonitrile,7-fluoro-4-hydroxy;3-Quinolinecarbonitrile,7-fluoro-1,4-dihydro-4-oxo;

Suppliers and Price of 3-Quinolinecarbonitrile, 7-fluoro-1,4-dihydro-4-oxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Quinolinecarbonitrile, 7-fluoro-1,4-dihydro-4-oxo-

Chemical Property:

PSA：56.65000
LogP:1.53888

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Quinolinecarbonitrile, 7-fluoro-1,4-dihydro-4-oxo-

There total 2 articles about 3-Quinolinecarbonitrile, 7-fluoro-1,4-dihydro-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 622369-68-0
ethyl 2-{[(1E)-(dimethylamino)methylidene]amino}-4-fluorobenzoate

: 75-05-8,26809-02-9
acetonitrile

: 622369-69-1,1008780-80-0
7-fluoro-4-oxo-3-quinolinecarbonitrile

Guidance literature:: acetonitrile; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.166667h;

ethyl 2-{[(1E)-(dimethylamino)methylidene]amino}-4-fluorobenzoate; In tetrahydrofuran; at -78 - -10 ℃;

With acetic acid; In tetrahydrofuran; at 20 ℃; for 72h; Further stages.;
DOI:10.1016/j.bmc.2007.09.028

Reference yield:

: 622369-68-0
ethyl 2-{[(1E)-(dimethylamino)methylidene]amino}-4-fluorobenzoate

: 75-05-8,26809-02-9
acetonitrile

: 622369-69-1,1008780-80-0
7-fluoro-4-hydroxyquinoline-3-carbonitrile

Guidance literature:: acetonitrile; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.166667h;

ethyl 2-{[(1E)-(dimethylamino)methylidene]amino}-4-fluorobenzoate; In tetrahydrofuran; at -78 - -10 ℃; for 3.5h;

With acetic acid; In tetrahydrofuran; at -78 - 20 ℃; for 72h;