Homo Sildenafil

Base Information

• Chemical Name: Homo Sildenafil
• CAS No.: 642928-07-2
• Molecular Formula: C23H32N6O4S
• Molecular Weight: 488.611
• Hs Code.: 29339900
• Mol file: 642928-07-2.mol

Synonyms:5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one;Homo Sildenafil

Chemical Property of Homo Sildenafil

Chemical Property:

• Appearance/Colour: White Solid
• Melting Point: 200-202°C
• Refractive Index: 1.656
• PSA: 121.80000
• Density: 1.37 g/cm³
• LogP: 2.95760
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

99% ^*data from raw suppliers

HomoSildenafil ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A new analogue of Sildenafil A new analogue of Sildenafil.

Technology Process of Homo Sildenafil

There total 5 articles about Homo Sildenafil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.5%

4-ethylpiperazine (5308-25-8) + 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (139756-22-2) → 5-[2-ethoxy-5-(4-ethylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (642928-07-2)

Guidance literature:

In ethanol; at 20 ℃; for 2h;

DOI:10.2174/157017811799304304

Reference yield:

2-ethoxylbenzaldehyde (613-69-4) → 5-[2-ethoxy-5-(4-ethylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (642928-07-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sulphonated graphene oxide / chloroform / 0.27 h / 120 °C / 12751.3 Torr / Flow reactor

2: chlorosulfonic acid / chloroform / 0.17 h / 25 °C / Flow reactor

3: chloroform / 0.08 h / 25 °C / Flow reactor

With chlorosulfonic acid; In chloroform;

DOI:10.1039/d1ra08220e

Reference yield:

5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one (139756-21-1) → 5-[2-ethoxy-5-(4-ethylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (642928-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid / chloroform / 0.17 h / 25 °C / Flow reactor

2: chloroform / 0.08 h / 25 °C / Flow reactor

With chlorosulfonic acid; In chloroform;

DOI:10.1039/d1ra08220e

upstream raw materials:

4-ethylpiperazine

5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

2-ethoxylbenzaldehyde

5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one

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