2-benzyl-2,8-diazaspiro[4.5]decane

Base Information

• Chemical Name: 2-benzyl-2,8-diazaspiro[4.5]decane
• CAS No.: 867009-61-8
• Molecular Formula: C₁₅H₂₂N₂
• Molecular Weight: 230.353
• Hs Code.: 2933990090
• Mol file: 867009-61-8.mol

Synonyms:2,8-diazaspiro[4.5]decane, 2-(phenylmethyl)-; 2-Benzyl-2,8-diazaspiro[4.5]decan

Chemical Property of 2-benzyl-2,8-diazaspiro[4.5]decane

Chemical Property:

• Vapor Pressure: 8.37E-05mmHg at 25°C
• Boiling Point: 340.8°C at 760 mmHg
• Flash Point: 134.1°C
• PSA: 15.27000
• Density: 1.07g/cm³
• LogP: 2.52880
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Benzyl-2,8-diazaspiro[4.5]decane ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-benzyl-2,8-diazaspiro[4.5]decane

There total 9 articles about 2-benzyl-2,8-diazaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-benzyl-2,8-diazaspiro[4.5]decan-1-one (716324-44-6) → 2-benzyl-2,8-diazaspiro[4.5]decane (867009-61-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Reflux;

Reference yield: 68.0%

2-benzyl-2,8-diaza-spiro[4.5]decane-1,3-dione (15882-48-1) → 2-benzyl-2,8-diazaspiro[4.5]decane (867009-61-8)

Guidance literature:

2-benzyl-2,8-diaza-spiro[4.5]decane-1,3-dione; With lithium aluminium tetrahydride; In tetrahydrofuran; at 5 - 20 ℃; for 4h;

With water; In tetrahydrofuran; at 0 ℃;

Reference yield:

2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester (236406-39-6) → 2-benzyl-2,8-diazaspiro[4.5]decane (867009-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium cyanoborohydride; acetic acid / methanol / 20 °C / pH 6 - 7

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1021/acsmedchemlett.7b00106

upstream raw materials:

2-benzyl-2,8-diaza-spiro[4.5]decane-1,3-dione

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

1-(1,1-dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate

4-(2-oxoethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

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