1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE

Base Information

• Chemical Name: 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE
• CAS No.: 268550-48-7
• Molecular Formula: C13H22N2O3
• Molecular Weight: 254.329
• Hs Code.: 2933990090
• Mol file: 268550-48-7.mol

Synonyms:1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE;TERT-BUTYL 1-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE;2,8-Diazaspiro[4.5]decane-8-carboxylicacid,1-oxo-,1,1-dimethylethylester;1-Oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester;1-Oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester;1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate;8-Boc-1-oxo-2,8-diazaspiro[4.5]decane

Chemical Property of 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE

Chemical Property:

• Vapor Pressure: 2E-07mmHg at 25°C
• Boiling Point: 424.9°C at 760 mmHg
• PKA: 16.00±0.20(Predicted)
• Flash Point: 210.8°C
• PSA: 58.64000
• Density: 1.15
• LogP: 1.79030
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE

There total 11 articles about 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.3%

4-(cyanomethyl)piperidine-1,4-dicarboxylic acid O1-tert-butyl O4-ethyl ester (495414-81-8) → 1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester (268550-48-7)

Guidance literature:

With sodium tetrahydroborate; cobalt(II) chloride hexahydrate; In methanol; at 60 ℃; for 52h; Cooling with ice;

DOI:10.1016/j.ejmech.2019.111669

Reference yield:

1-tert-butyl 4-methyl 4-(cyanomethyl)piperidine-1,4-dicarboxylate (1350475-42-1) → 1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester (268550-48-7)

Guidance literature:

With ammonium hydroxide; hydrogen; In methanol; at 50 ℃; for 18h; under 15001.5 Torr;

Reference yield:

2,8-diaza-spiro[4.5]decan-1-one hydrochloride (832710-65-3) + di-tert-butyl dicarbonate (24424-99-5) → 1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester (268550-48-7)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; water; pH=~ 10;

upstream raw materials:

2,8-diaza-spiro[4.5]decan-1-one hydrochloride

di-tert-butyl dicarbonate

4-carbethoxypiperidine

1-tert-butyl 4-ethyl 4-(2-chloroethyl)piperidine-1,4-dicarboxylate

Downstream raw materials:

2-(4-chloro-3-methoxy-phenyl)-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester

2-(4-bromobenzyl)-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester

C₂₇H₂₉FN₂O

2,8-diazaspiro[4,5]decane-1-one

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