832710-65-3

Basic information

• Product Name: 2,8-Diazaspiro[4.5]decan-1-one, hydrochloride (1:1)
• Synonyms: 2,8-Diazaspiro[4.5]decan-1-one, hydrochloride (1:1);3,8-Diazaspiro[4.5]decan-4-one hydrochloride;2,8-Diazaspiro 4.5 decan-1-one, hydrochloride (1
• CAS NO: 832710-65-3
• Molecular Formula: C₈H₁₄N₂O*ClH
• Molecular Weight: 190.67
• Mol File: 832710-65-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 383.2°C at 760 mmHg
• Flash Point: 185.5°C
• Appearance: /
• Vapor Pressure: 3.01E-06mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2,8-Diazaspiro[4.5]decan-1-one, hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,8-Diazaspiro[4.5]decan-1-one, hydrochloride (1:1)(832710-65-3)
• EPA Substance Registry System: 2,8-Diazaspiro[4.5]decan-1-one, hydrochloride (1:1)(832710-65-3)

Safety Data

• Hazardous Substances Data: 832710-65-3(Hazardous Substances Data)

Usage

General Description

2,8-Diazaspiro[4.5]decan-1-one, hydrochloride (1:1) is a chemical compound consisting of a 1:1 ratio of 2,8-diazaspiro[4.5]decan-1-one and hydrochloride. 2,8-Diazaspiro[4.5]decan-1-one, hydrochloride (1:1) is a spirocyclic compound with a diazaspirodecane core structure, and the hydrochloride salt form of the compound is commonly used in pharmaceuticals and chemical research. It may have potential applications as a central nervous system depressant or as an analgesic, and it has been studied for its effects on various neurotransmitter systems. 2,8-Diazaspiro[4.5]decan-1-one, hydrochloride (1:1) is thus an important chemical with potential pharmacological and research applications.

InChI:InChI=1/C8H14N2O.ClH/c11-7-8(3-6-10-7)1-4-9-5-2-8;/h9H,1-6H2,(H,10,11);1H

Upstream product

• 268550-48-7 1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester 

Downstream Products

• 832710-62-0 8-(3,3-diphenylpropyl)-2,8-diaza-spiro[4.5]decan-1-one 
• 268550-48-7 1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester 
• 1257999-90-8 C₂₁H₂₂F₂N₂O 
• 1349632-86-5 8-({4-[(trifluoromethyl)oxy]phenyl}sulfonyl)-2,8-diazaspiro[4.5]decan-1-one 
• 1349632-83-2 8-{[3-(trifluoromethyl)phenyl]sulfonyl}-2,8-diazaspiro[4.5]decan-1-one 
• 1349632-78-5 8-{[4-(trifluoromethyl)phenyl]sulfonyl}-2,8-diazaspiro[4.5]decan-1-one 
• 1349633-04-0 2-(2,2,2-trifluoroethyl)-8-{[4-(trifluoromethyl)phenyl]sulfonyl}-2,8-diazaspiro[4.5]decan-1-one 
• 1349633-00-6 8-[(3,5-dichlorophenyl)-sulfonyl]-2,8-diazaspiro[4.5]decan-1-one 
• 1349632-73-0 8-{[2-chloro-4-(trifluoromethyl)phenyl]sulfonyl}-2,8-diazaspiro[4.5]decan-1-one 
• 1349632-98-9 8-({3-[(trifluoromethyl)oxy]phenyl}-sulfonyl)-2,8-diazaspiro[4.5]decan-1-one 
• 1349633-18-6 8-{[2-bromo-4-(trifluoromethyl)phenyl]sulfonyl}-2,8-diazaspiro[4.5]decan-1-one 
• 1349633-16-4 8-{[3-bromo-5-(trifluoromethyl)phenyl]sulfonyl}-2,8-diazaspiro[4.5]decan-1-one 
• 1349633-20-0 8-{[2-bromo-5-(trifluoromethyl)phenyl]sulfonyl}-2,8-diazaspiro[4.5]decan-1-one 
• 1349633-02-8 8-({3-chloro-4-[(trifluoromethyl)oxy]phenyl}sulfonyl)-2,8-diazaspiro[4.5]decan-1-one 

Relevant articles and documents

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

HETEROCYCLIC COMPOUND

An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof.