832710-65-3

Usage

Uses

Used in Pharmaceutical Industry:
2,8-Diazaspiro[4.5]decan-1-one, hydrochloride (1:1) is used as a central nervous system depressant for its potential calming effects on the nervous system, which may be beneficial in treating conditions characterized by excessive nervous system activity.
Used in Pain Management:
In the field of pain management, 2,8-Diazaspiro[4.5]decan-1-one, hydrochloride (1:1) is used as an analgesic, potentially providing relief from pain by interacting with neurotransmitter systems involved in pain perception.
Used in Chemical Research:
2,8-Diazaspiro[4.5]decan-1-one, hydrochloride (1:1) is utilized as a research compound for studying its effects on various neurotransmitter systems, which can contribute to the development of new pharmaceuticals and a better understanding of neurological processes.

InChI:InChI=1/C8H14N2O.ClH/c11-7-8(3-6-10-7)1-4-9-5-2-8;/h9H,1-6H2,(H,10,11);1H

Upstream product

• 268550-48-7 1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester 

Downstream Products

• 1257999-90-8 C₂₁H₂₂F₂N₂O 
• 1383453-28-8 C₁₅H₁₉N₃O₃ 
• 1383452-66-1 C₂₂H₂₃BrN₄O₄ 
• 1383452-98-9 C₂₈H₃₀N₄O₅ 
• 1383453-27-7 C₁₅H₁₇N₃O₅ 
• 1383452-70-7 C₂₂H₂₂ClFN₄O₄ 
• 1354946-05-6 8-({1-[3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2,8-diazaspiro[4.5]decan-1-one 
• 1349633-02-8 8-({3-chloro-4-[(trifluoromethyl)oxy]phenyl}sulfonyl)-2,8-diazaspiro[4.5]decan-1-one 
• 1349633-20-0 8-{[2-bromo-5-(trifluoromethyl)phenyl]sulfonyl}-2,8-diazaspiro[4.5]decan-1-one 
• 1349633-16-4 8-{[3-bromo-5-(trifluoromethyl)phenyl]sulfonyl}-2,8-diazaspiro[4.5]decan-1-one 
• 1349633-18-6 8-{[2-bromo-4-(trifluoromethyl)phenyl]sulfonyl}-2,8-diazaspiro[4.5]decan-1-one 
• 1349632-98-9 8-({3-[(trifluoromethyl)oxy]phenyl}-sulfonyl)-2,8-diazaspiro[4.5]decan-1-one 
• 1349632-73-0 8-{[2-chloro-4-(trifluoromethyl)phenyl]sulfonyl}-2,8-diazaspiro[4.5]decan-1-one 
• 1349633-00-6 8-[(3,5-dichlorophenyl)-sulfonyl]-2,8-diazaspiro[4.5]decan-1-one 

Relevant academic research and scientific papers

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

HETEROCYCLIC COMPOUND

An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof.