6-Methoxychroman-4-amine

Base Information

• Chemical Name: 6-Methoxychroman-4-amine
• CAS No.: 81816-60-6
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.219
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID90510002
• Mol file: 81816-60-6.mol

Synonyms:6-methoxychroman-4-amine;81816-60-6;6-methoxy-3,4-dihydro-2H-chromen-4-amine;6-methoxy-3,4-dihydro-2H-1-benzopyran-4-amine;6-methoxychroman-4-ylamine;SCHEMBL1239052;DTXSID90510002;APTWFKUWDZQXHL-UHFFFAOYSA-N;MFCD07374070;AKOS002674555;AKOS016042432;AB38671;AB38673;AB38676;AC-31649;AM20041199;CS-0456007;FT-0739168;FT-0771476;FT-0773941;EN300-84064;A15062;A15825;I11419

Chemical Property of 6-Methoxychroman-4-amine

Chemical Property:

• Vapor Pressure: 0.00696mmHg at 25°C
• Boiling Point: 270.1°C at 760 mmHg
• Flash Point: 126.9°C
• PSA: 44.48000
• Density: 1.128g/cm³
• LogP: 2.17780
• Storage Temp.: 2-8°C
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 179.094628657
• Heavy Atom Count: 13
• Complexity: 174

Purity/Quality:

97% ^*data from raw suppliers

6-Methoxychroman-4-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)OCCC2N

Technology Process of 6-Methoxychroman-4-amine

There total 3 articles about 6-Methoxychroman-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methoxy-chroman-4-one oxime (67858-18-8) → 6-methoxychroman-4-amine (81816-60-6)

Guidance literature:

With hydrogen; nickel; In ethanol;

Reference yield:

6-methoxychroman-4-one (5802-17-5) → 6-methoxychroman-4-amine (81816-60-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride, potassium carbonate / ethanol

2: hydrogene / Raney nickel / ethanol

With hydroxylamine hydrochloride; hydrogen; potassium carbonate; nickel; In ethanol;

Reference yield:

→ 6-methoxychroman-4-amine (81816-60-6)

Guidance literature:

upstream raw materials:

6-methoxy-chroman-4-one oxime

6-methoxychroman-4-one

Downstream raw materials:

1-(6-Methoxy-chroman-4-yl)-4-(2-methoxy-phenyl)-piperazine; hydrochloride

1-(6-Methoxy-chroman-4-yl)-4-(4-methoxy-phenyl)-piperazine; hydrochloride

1-(6-Methoxy-chroman-4-yl)-4-phenyl-piperazine