Technology Process of 4-[(2S)-2-Methylbutyl]-1,1'-biphenyl
There total 4 articles about 4-[(2S)-2-Methylbutyl]-1,1'-biphenyl which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-bromo-1,1'-biphenyl;
With
magnesium;
In
tetrahydrofuran;
for 1h;
Inert atmosphere;
Reflux;
(S)-2-methylbutyl bromide;
With
dilithium tetrachlorocuprate;
In
tetrahydrofuran;
for 48h;
Reflux;
Inert atmosphere;
DOI:10.1016/j.tetlet.2013.04.118
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 24.5 g / pyridine / 1 h / 0 - 5 °C
2: 70 percent / lithium bromide / acetone / Ambient temperature
3: 1.) magnesium, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride / 1.) ether, 2.) ether, reflux, 5 h
With
pyridine; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); magnesium; lithium bromide;
In
acetone;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 70 percent / lithium bromide / acetone / Ambient temperature
2: 1.) magnesium, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride / 1.) ether, 2.) ether, reflux, 5 h
With
1,3-bis[(diphenylphosphino)propane]dichloronickel(II); magnesium; lithium bromide;
In
acetone;
