2-(diethoxymethyl)-5,6-difluoro-1H-benzo[d]imidazole

Base Information

• Chemical Name: 2-(diethoxymethyl)-5,6-difluoro-1H-benzo[d]imidazole
• CAS No.: 958863-36-0
• Molecular Formula: C12H14F2N2O2
• Molecular Weight: 256.252
• Hs Code.: 2933990090
• Mol file: 958863-36-0.mol

Synonyms:2-(diethoxymethyl)-5,6-difluoro-1H-benzo[d]imidazole

Chemical Property of 2-(diethoxymethyl)-5,6-difluoro-1H-benzo[d]imidazole

Chemical Property:

• PSA: 47.14000
• Density: 1.285
• LogP: 2.91270
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-(Diethoxymethyl)-5,6-difluoro-1H-benzo[d]imidazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(diethoxymethyl)-5,6-difluoro-1H-benzo[d]imidazole

There total 5 articles about 2-(diethoxymethyl)-5,6-difluoro-1H-benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-diethoxy-N-methylacetamide (1331832-22-4) + 2-amino-4,5-difluoroaniline (76179-40-3) → 2-(diethoxymethyl)-5,6-difluoro-1H-benzimidazole (958863-36-0)

Guidance literature:

2,2-diethoxy-N-methylacetamide; 2-amino-4,5-difluoroaniline; With acetic acid; In methanol; at 20 ℃; for 16h;

With potassium carbonate; In water;

Reference yield:

4,5-difluoro-2-nitroaniline (78056-39-0) + 2,2-diethoxy-ethanimidic acid methyl ester (76742-48-8) → 2-(diethoxymethyl)-5,6-difluoro-1H-benzimidazole (958863-36-0)

Guidance literature:

4,5-difluoro-2-nitroaniline; With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 3h;

2,2-diethoxy-ethanimidic acid methyl ester; With acetic acid; In methanol; at 20 ℃; for 16h;

Reference yield:

4,5-difluoro-2-nitroaniline (78056-39-0) → 2-(diethoxymethyl)-5,6-difluoro-1H-benzimidazole (958863-36-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

2: acetic acid / methanol / 16 h / 20 °C

With hydrogen; acetic acid; palladium 10% on activated carbon; In methanol;

upstream raw materials:

2,2-diethoxy-N-methylacetamide

2-amino-4,5-difluoroaniline

4,5-difluoro-2-nitroaniline

2,2-diethoxy-ethanimidic acid methyl ester

Downstream raw materials:

2-(diethoxymethyl)-5,6-difluoro-1-methyl-1H-benzimidazole

5,6-difluoro-1-methyl-1H-benzimidazole-2-carbaldehyde