Technology Process of THS 21-glucuronide
There total 20 articles about THS 21-glucuronide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: H2SO4 / ethanol; dioxane / 1 h / Ambient temperature
2: H2 / 5percent Pd-C / ethanol; ethyl acetate / 14 h
3: 2N HCl / H2O
4: NaOH / methanol; dioxane
5: pyridinium p-toluenesulfonate / CH2Cl2 / 3 h / Ambient temperature
6: 74 percent / potassium tri-sec-butylborohydride / tetrahydrofuran / -78 °C
7: pyridine / 20 h / Ambient temperature
8: 50percent H2SO4 / acetone / 0.67 h / Ambient temperature
9: Ag2CO3 / toluene / 12 h / Ambient temperature
10: 2percent KOH / methanol / 12 h / Ambient temperature
With
pyridine; hydrogenchloride; potassium hydroxide; sodium hydroxide; sulfuric acid; hydrogen; pyridinium p-toluenesulfonate; potassium tri-sec-butyl-borohydride; silver carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; acetone; toluene;
DOI:10.1248/cpb.33.4281
- Guidance literature:
-
Multi-step reaction with 9 steps
1: H2 / 5percent Pd-C / ethanol; ethyl acetate / 14 h
2: 2N HCl / H2O
3: NaOH / methanol; dioxane
4: pyridinium p-toluenesulfonate / CH2Cl2 / 3 h / Ambient temperature
5: 74 percent / potassium tri-sec-butylborohydride / tetrahydrofuran / -78 °C
6: pyridine / 20 h / Ambient temperature
7: 50percent H2SO4 / acetone / 0.67 h / Ambient temperature
8: Ag2CO3 / toluene / 12 h / Ambient temperature
9: 2percent KOH / methanol / 12 h / Ambient temperature
With
pyridine; hydrogenchloride; potassium hydroxide; sodium hydroxide; sulfuric acid; hydrogen; pyridinium p-toluenesulfonate; potassium tri-sec-butyl-borohydride; silver carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; acetone; toluene;
DOI:10.1248/cpb.33.4281
- Guidance literature:
-
Multi-step reaction with 6 steps
1: pyridinium p-toluenesulfonate / CH2Cl2 / 3 h / Ambient temperature
2: 74 percent / potassium tri-sec-butylborohydride / tetrahydrofuran / -78 °C
3: pyridine / 20 h / Ambient temperature
4: 50percent H2SO4 / acetone / 0.67 h / Ambient temperature
5: Ag2CO3 / toluene / 12 h / Ambient temperature
6: 2percent KOH / methanol / 12 h / Ambient temperature
With
pyridine; potassium hydroxide; sulfuric acid; pyridinium p-toluenesulfonate; potassium tri-sec-butyl-borohydride; silver carbonate;
In
tetrahydrofuran; methanol; dichloromethane; acetone; toluene;
DOI:10.1248/cpb.33.4281
