640-87-9 Usage
Description
REICHSTEIN'S SUBSTANCE S 21-ACETATE, also known as 17α-Hydroxy-11-deoxycorticosterone-21-acetate (Hydrocortisone EP Impurity K), is a synthetic steroid acetate substance 'S' that functions as a carbaryl synergist. It is a derivative of the naturally occurring hormone cortisol, with an acetate group attached to the 21st carbon atom, which enhances its lipophilic properties and allows for better absorption and distribution in the body.
Uses
Used in Pesticide Industry:
REICHSTEIN'S SUBSTANCE S 21-ACETATE is used as a carbaryl synergist for enhancing the effectiveness of carbaryl-based insecticides. As a synthetic steroid, it works by interfering with the endocrine system of insects, making them more susceptible to the toxic effects of carbaryl. This results in improved pest control and reduced chemical usage, leading to more sustainable and environmentally friendly agricultural practices.
Used in Pharmaceutical Industry:
REICHSTEIN'S SUBSTANCE S 21-ACETATE is used as an intermediate in the synthesis of various corticosteroid drugs. Corticosteroids are a class of steroid hormones that have potent anti-inflammatory and immunosuppressive properties. They are widely used in the treatment of various medical conditions, such as allergies, asthma, arthritis, and autoimmune diseases. By serving as a key intermediate in the production of these drugs, REICHSTEIN'S SUBSTANCE S 21-ACETATE plays a crucial role in the development and manufacturing of life-saving medications.
Used in Research and Development:
REICHSTEIN'S SUBSTANCE S 21-ACETATE is also used as a research tool in the study of steroid hormones and their effects on various biological processes. It can be employed in laboratory experiments to investigate the mechanisms of action, metabolism, and pharmacokinetics of corticosteroids. Additionally, it can be used to develop new synthetic steroids with improved therapeutic properties or novel applications in various fields, such as medicine, agriculture, and environmental management.
Check Digit Verification of cas no
The CAS Registry Mumber 640-87-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,4 and 0 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 640-87:
(5*6)+(4*4)+(3*0)+(2*8)+(1*7)=69
69 % 10 = 9
So 640-87-9 is a valid CAS Registry Number.
640-87-9Relevant articles and documents
Effect of C-21 Substituents on the Elimination of a 17α-Acyloxy Group from 17α-(Acyloxy)-20-oxo Steroids
Solo, A. J.,Suto, Mark
, p. 2012 - 2013 (1980)
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A by the 3,17-dione steroid preparing steroid the synthetic method of the compound of
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, (2017/03/14)
The invention discloses a synthetic method of steroid type drugs and intermediates, in particular relates to a synthetic method for preparing 17-hydroxy-20-ketone steroid compounds from 3,17-diketone steroids, and belongs to the field of synthesis of drugs. The method takes 3,17-diketone steroids as raw materials and adopts a conventional, environment-friendly, low-toxicity reagent, and the steroid type drugs such as cortisone, hydrocortisone, metacortandracin, or hydroprednisone, or intermediates 17alpha-hydroxy-20-ketone compounds are prepared simply and conveniently at high yield by selective protection of C3 or (and) C11-ketone group, Wittig reaction of C17, selective oxidization of 17(20)-position double bonds and halogenating replacement. The aftertreatment is simple, few three wastes are generated, the reaction selectivity is good, the yield is high, and byproducts anti-pregnancy steroidal drugs and steroidal compounds can be obtained. The raw materials are easy to get, the cost is low and the synthetic process is simple; the synthetic method is suitable for industrial production.
An efficient hemisynthesis of 20- and 21-[13C]-labeled cortexolone: A model for the study of skin sensitization to corticosteroids
Claudel, Emilie,Arbez-Gindre, Cecile,Berl, Valerie,Lepoittevin, Jean-Pierre
scheme or table, p. 3391 - 3398 (2010/02/28)
A method is described for the synthesis of isotopomers of cortexolone from the commercially available andros-4-ene-3, 17dione. The strategy is based on the use of K13CN for labeling at position 20 and of 13CH 3Mgl, generated in situ, for labeling at position 21. Because of the early introduction of the [13C] labeling, our efforts aimed at reproducible experimental procedures giving high yields with respect to the isotope containing precursors. During the development of this hemisynthesis, we noted that judicious choice of protective groups was essential as this could lead not only to mixtures or unstable intermediates but also influence considerably the output of reactions.
