C₃₃H₃₅F₆NO₇Si

Base Information

• Chemical Name: C₃₃H₃₅F₆NO₇Si
• CAS No.: 1562377-20-1
• Molecular Formula: C₃₃H₃₅F₆NO₇Si
• Molecular Weight: 699.719
• Mol file: 1562377-20-1.mol

Synonyms:

Chemical Property of C₃₃H₃₅F₆NO₇Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₃₅F₆NO₇Si

There total 5 articles about C₃₃H₃₅F₆NO₇Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H25NO3 (1562377-09-6) + tert-butyldimethylsilyl chloride (18162-48-6) + bis(2,2,2-trifluoroethyl) acetylenedicarboxylate → C33H35F6NO7Si (1562377-20-1) + C33H35F6NO7Si (1562377-35-8)

Guidance literature:

C₂₃H₂₅NO₃; With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; at -78 ℃; Molecular sieve; Inert atmosphere;

tert-butyldimethylsilyl chloride; In tetrahydrofuran; at -78 - 20 ℃; for 7h; Molecular sieve; Inert atmosphere;

bis(2,2,2-trifluoroethyl) acetylenedicarboxylate; at 150 ℃; Overall yield = 108 mg; regioselective reaction; Sealed tube; Inert atmosphere;

DOI:10.1021/ol4034447

Reference yield:

5,5-dimethyl-3-benzylamino-2-cyclohexen-1-one (889-31-6) → C33H35F6NO7Si (1562377-20-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C / Molecular sieve; Inert atmosphere

1.2: -78 - 20 °C / Molecular sieve; Inert atmosphere

2.1: n-butyllithium; potassium tert-butylate / tetrahydrofuran / -78 °C / Molecular sieve; Inert atmosphere

2.2: 7 h / -78 - 20 °C / Molecular sieve; Inert atmosphere

2.3: 255 / 150 °C / Sealed tube; Inert atmosphere

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran;

DOI:10.1021/ol4034447

Reference yield:

benzylamine (100-46-9) → C33H35F6NO7Si (1562377-20-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid; sodium sulfate / benzene / 85 °C / Sealed tube; Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C / Molecular sieve; Inert atmosphere

2.2: -78 - 20 °C / Molecular sieve; Inert atmosphere

3.1: n-butyllithium; potassium tert-butylate / tetrahydrofuran / -78 °C / Molecular sieve; Inert atmosphere

3.2: 7 h / -78 - 20 °C / Molecular sieve; Inert atmosphere

3.3: 255 / 150 °C / Sealed tube; Inert atmosphere

With n-butyllithium; potassium tert-butylate; toluene-4-sulfonic acid; sodium sulfate; In tetrahydrofuran; benzene;

DOI:10.1021/ol4034447

upstream raw materials:

C₂₉H₃₉NO₃Si

5,5-dimethyl-3-benzylamino-2-cyclohexen-1-one

C₂₃H₂₅NO₃

tert-butyldimethylsilyl chloride